SILC is a safe and feasible approach in selected patients. The main advantages are a better cosmetic result and less pain.

Previous studies have detected abnormal serum ferritin levels in patients with depression; however, the results have been inconsistent. This study used quantitative susceptibility mapping (QSM) for the first time to examine brain iron concentration in depressed patients and evaluated whether it is related to severity. We included three groups of age- and gender-matched participants: 30 patients with mild-moderate depression (MD), 14 patients with major depression disorder (MDD) and 20 control subjects. All participants underwent MR scans with a 3D gradient-echo sequence reconstructing for QSM and performed the 17-item Hamilton Depression Rating Scale (HDRS) test. In MDD, the susceptibility value in the bilateral putamen was significantly increased compared with MD or control subjects. In addition, a significant difference was also observed in the left thalamus in MDD patients compared with controls. However, the susceptibility values did not differ between MD patients and controls. The susceptibility values positively correlated with the severity of depression as indicated by the HDRS scores. Our results provide evidence that brain iron deposition may be associated with depression and may even be a biomarker for investigating the pathophysiological mechanism of depression.

LESSC is a safe and feasible procedure in selected patients with benign gallbladder diseases, with the significant advantage of cosmesis.

The glucocorticoid receptor (GR) is the main effector of the activation of the hypothalamus-pituitary-adrenal (HPA) axis, which is caused by different types of stress that can be divided into two major categories: physical stress and psychological stress. Given the marked presence of GR in the hippocampus, GR-mediated hippocampal injury might be the core event under stress. The aim of this study was to investigate GR expression, hippocampal injury, and behaviors in rats to explore the differences between these types of stressors. Adult male rats were stressed using a classical model (electrical foot shock and a yoked psychologically stressful situation) to induce physical or psychological stress. The GR expression, injury of hippocampal subfields and behavioral abnormalities were dynamic, as demonstrated using immunofluorescence, 3D magnetic resonance imaging (MRI) and open field exploration (OFE), respectively. In addition, housing in a normal environment for 6 weeks was used to verify the recovery ability of rats. First, GR-mediated hippocampal atrophy and behavioral abnormalities were found in the second week under physical stress, but those changes did not appear until the fourth week under psychological stress. Second, the effects of stress were more pronounced after physical stressors than after psychological stressors in the fourth week, but this trend had reversed by the sixth week, especially in the DG (Dentate Gyrus) subfield. Except for the rats that had experienced 6 weeks of psychological stress, all rats showed significant recovery after 6 weeks of housing in a normal environment. The effects of physical stress appeared early but were relatively moderate, whereas the effects of psychological stress appeared late but were more severe. In addition, GR-mediated serious injury in the DG might be the cause of the DG volume loss and behaviors that could not be reversed.

No abstract