Although proton conductors derived from metal-organic frameworks (MOFs) are highly anticipated for various applications including solid-state electrolytes, H sensors, and ammonia synthesis, they are facing serious challenges such as poor water stability, fastidious working conditions, and low proton conductivity. Herein, we report two lanthanide-oxalate MOFs that are highly water stable, with so far the highest room-temperature proton conductivity (3.42 × 10 S cm ) under 100% relative humidity (RH) among lanthanide-based MOFs and, most importantly, luminescent. Moreover, the simultaneous response of both the proton conductivity and luminescence intensity to RH allows the linkage of proton conductivity with luminescence intensity. This way, the electric signal of proton conductivity variation versus RH will be readily translated to optical signal of luminescence intensity, which can be directly visualized by the naked eye. If proper lanthanide ions or even transition-metal ions are used, the working wavelengths of luminescence emissions can be further extended from visible to near infrared light for even wider-range applications.

The movement disorder Parkinson’s disease (PD) is the second most frequently diagnosed neurodegenerative disease, and is associated with aging, the environment, and genetic factors. The intracellular aggregation of α-synuclein and the loss of dopaminergic neurons in the substantia nigra pars compacta are the pathological hallmark of PD. At present, there is no successful treatment for PD. Maackiain (MK) is a flavonoid extracted from dried roots of Sophora flavescens Aiton. MK has emerged as a novel agent for PD treatment that acts by inhibiting monoamine oxidase B. In this study, we assessed the neuroprotective potential of MK in Caenorhabditis elegans and investigated possible mechanism of this neuroprotection in the human SH-SY5Y cell line. We found that MK significantly reduced dopaminergic neuron damage in 6-hydroxydopamine (6-OHDA)-exposed worms of the BZ555 strain, with corresponding improvements in food-sensing behavior and life-span. In transgenic worms of strain NL5901 treated with 0.25 mM MK, the accumulation of α-synuclein was diminished by 27% (p < 0.01) compared with that in untreated worms. Moreover, in worms and the SH-SY5Y cell line, we confirmed that the mechanism of MK-mediated protection against PD pathology may include blocking apoptosis, enhancing the ubiquitin-proteasome system, and augmenting autophagy by increasing PINK1/parkin expression. The use of small interfering RNA to downregulate parkin expression in vivo and in vitro could reverse the benefits of MK in PD models. MK may have considerable therapeutic applications in PD.

The flame retardancy of polyethylenes can be efficiently improved through the palladium catalyzed copolymerization of ethylene with polar comonomers.

Although all‐polymer solar cells (all‐PSCs) show great commercialization prospects, their power conversion efficiencies (PCEs) still fall behind their small molecule acceptor‐based counterparts. In all‐polymer blends, the optimized morphology and high molecular ordering are difficult to achieve since there is troublesome competition between the crystallinity of the polymer donor and acceptor during the film‐formation process. Therefore, it is challenging to improve the performance of all‐PSCs. Herein, a ternary strategy is adopted to modulate the morphology and the molecular crystallinity of an all‐polymer blend, in which PM6:PY‐82 is selected as the host blend and PY‐DT is employed as a guest component. Benefiting from the favorable miscibility of the two acceptors and the higher regularity of PY‐DT, the ternary matrix features a well‐defined fibrillar morphology and improved molecular ordering. Consequently, the champion PM6:PY‐82:PY‐DT device produces a record‐high PCE of 18.03%, with simultaneously improved open‐circuit voltage, short‐circuit current and fill factor in comparison with the binary devices. High‐performance large‐area (1 cm2) and thick‐film (300 nm) all‐PSCs are also successfully fabricated with PCEs of 16.35% and 15.70%, respectively.Moreover, 16.5 cm2 organic solar module affords an encouraging PCE of 13.84% when using the non‐halogenated solvent , showing the great potential of “Lab‐to‐Fab” transition of all‐PSCs.