A one-pot protocol for the Cu­(I)-catalyzed difunctionalization of indolyl ynones has been achieved via trifluoromethylation of alkyne followed by dearomatizing spirocyclization of indoles. This cascade process enables constructing diverse CF3-containing spiro­[cyclopentane-1,3′-indole] scaffolds in moderate to excellent yields which have challenging quaternary spirocyclic carbon and tetrasubstituted alkenes.

An efficient method for the synthesis of difluoroalkylated 2-azaspiro[4.5]decanes via copper-catalyzed difluoromethylation of N-benzylacrylamides with ethyl bromodifluoroacetate has been established. The reaction experienced a tandem radical addition, dearomatizating cyclization process....

A general and efficient strategy synthesis of aurones by carbonylation reaction of aryl bromides and terminal aromatic alkynes using CO2 has been established. Various terminal aromatic alkynes and 2‐bromophenol by using CO2 with hydrosilane could be leveraged to provide various aurones in good yields under mild reaction conditions. Moreover, palladium‐catalyzed carbonylation reaction mechanism is proposed for the preparation of aurones.