An environmentally friendly strategy for the photocatalyzed three-component reaction between quinoxalinones, alkenes, and hypervalent iodine­(III) reagents is disclosed. The new designed difluoroiodane­(III) reagent shows excellent reactivity, providing a wide range of difluoroalkyl-substituted quinoxaline-2­(1H)-ones in moderate to excellent yields under mild conditions. Experimental studies demonstrated that a difluoroalkyl radical intermediate was involved in this reaction.

The direct introduction of diverse fluorinated motifs into feedstock molecules and advanced intermediates is widely studied in pharmaceutical research and drug development. Among the emerging motifs, the difluoromethyl CF2H is...

A series of novel fluoro‐containing hypervalent iodane (III) reagents was designed and synthesized. By employing these novel hypervalent iodane (III) reagents, an efficient visible‐light‐triggered radical cyclization of alkynoates to diversely 3‐fluoroalkylated coumarins was developed under metal free condition. It provided an alternative and environmental friendly approach for the installation of 3‐fluoroalkyl motif into synthetically valuable building block coumarins.