Background COVID-19 was first discovered in December 2019 and has since evolved into a pandemic. Objective To address this global health crisis, artificial intelligence (AI) has been deployed at various levels of the health care system. However, AI has both potential benefits and limitations. We therefore conducted a review of AI applications for COVID-19. Methods We performed an extensive search of the PubMed and EMBASE databases for COVID-19–related English-language studies published between December 1, 2019, and March 31, 2020. We supplemented the database search with reference list checks. A thematic analysis and narrative review of AI applications for COVID-19 was conducted. Results In total, 11 papers were included for review. AI was applied to COVID-19 in four areas: diagnosis, public health, clinical decision making, and therapeutics. We identified several limitations including insufficient data, omission of multimodal methods of AI-based assessment, delay in realization of benefits, poor internal/external validation, inability to be used by laypersons, inability to be used in resource-poor settings, presence of ethical pitfalls, and presence of legal barriers. AI could potentially be explored in four other areas: surveillance, combination with big data, operation of other core clinical services, and management of patients with COVID-19. Conclusions In view of the continuing increase in the number of cases, and given that multiple waves of infections may occur, there is a need for effective methods to help control the COVID-19 pandemic. Despite its shortcomings, AI holds the potential to greatly augment existing human efforts, which may otherwise be overwhelmed by high patient numbers.

BACKGROUND Coronavirus Disease 2019 (COVID-19) was first discovered in December 2019 and has since evolved into a pandemic. To address this global health crisis, artificial intelligence (AI) has been deployed at various levels of the healthcare system. OBJECTIVE However, AI has both potential benefits and limitations. We therefore conducted a comprehensive review of AI applications for COVID-19. METHODS We performed an extensive search of the PubMed and Embase databases for COVID-19-related English-language studies published between 1/12/2019 and 31/3/2020. We supplemented the database search with reference list checks. Thematic analysis and narrative review of AI applications for COVID-19 documented was conducted. RESULTS 11 papers were included for review. AI was applied to COVID-19 in four areas: diagnosis, public health, clinical decision-making, and therapeutics. We identified several limitations including insufficient data, omission of multimodal methods of AI-based assessment, delay in realization of benefits, poor internal/external validation, inability to be used by laypersons, inability to be used in resource-poor settings, presence of ethical pitfalls and presence of legal barriers. AI could potentially be explored in four other areas: surveillance, combination with big data, operation of other core clinical services, and management of COVID-19 patients. CONCLUSIONS In view of the continuing increase in infected cases, and given that multiple waves of infections may occur, there is need for effective methods to help control the COVID-19 pandemic. Despite its shortcomings, AI holds the potential to greatly augment existing human efforts, which may otherwise be overwhelmed by large patient numbers.

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