Herbs and spices have been used for generations by humans as food and to treat ailments. Scientific evidence is accumulating that many of these herbs and spices do have medicinal properties that alleviate symptoms or prevent disease. A growing body of research has demonstrated that the commonly used herbs and spices such as garlic, black cumin, cloves, cinnamon, thyme, allspices, bay leaves, mustard, and rosemary, possess antimicrobial properties that, in some cases, can be used therapeutically. Other spices, such as saffron, a food colorant; turmeric, a yellow colored spice; tea, either green or black, and flaxseed do contain potent phytochemicals, including carotenoids, curcumins, catechins, lignan respectively, which provide significant protection against cancer. This review discusses recent data on the antimicrobial and chemopreventive activities of some herbs and spices and their ingredients.

The control of pharmaceutical impurities is currently a critical issue to the pharmaceutical industry. The International Conference on Harmonization (ICH) has formulated a workable guideline regarding the control of impurities. In this review, a description of different types and origins of impurities in relation to ICH guidelines and, degradation routes, including specific examples, are presented. The article further discusses measures regarding the control of impurities in pharmaceuticals.

A combination of crushed garlic (Allium sativum) and black cumin seeds (Nigelia sativum) has been used as a traditional remedy for urinary tract infections. In-vitro antimicrobial testing suggested that the mixture of two spices in the ratio of 1:1 has antimicrobial effects on both Staphylococcus aureus and Escherichia coli species. Analyses of the extract of garlic and black cumin by GC-MS as well as LC-MS & MS 2 confirmed that the main components of garlic were allicin, γ-glutamyl-S-allylcysteine and allicin transformed products such as diallyldisulfide and vinyldithiins. Components of black cumin were thymoquinone, p-cymene, p-tert-butylcatechol, and pinene. Isolated samples of allicin by preparative HPLC from garlic extract and reference samples of diallyldisulfide and thymoquinone were tested individually and in combination for their antimicrobial activities against S. aureus and E. coli. All of these compounds showed modest antimicrobial effects individually (except diallyldisulfide against E. coli) and in combination.

In Bangladesh, the government healthcare system remains a very minor source of health care for rural households. The availability of registered physicians is scare in rural areas, and the people, the majority of whom are underweight as indicated by body mass index measurement have to depend on pharmacy salespersons, quacks and herbal or spiritual healers. Unlike Australia, almost every pharmacy salesperson illegally recommends and sells prescription medicines. In addition, there are also unqualified village 'doctors' who do not own a pharmacy shop but provide written prescriptions. However, the treatments provided by these village 'doctors' remain open to question, with instances of maltreatment or inadequate treatment. The treatments are mostly symptomatic and polypharmacy is common, with antibiotics and vitamins prescribed widely. On the other hand, rural people sometimes do not buy all the drugs that are prescribed for them, partly because of financial constraint. In addition, self-medication is common. While family planning and immunisation are slowly becoming popular among rural families, general health knowledge is still poor. Public healthcare campaigns as well as proper training for the rural prescribers could be helpful in improving the present poor rural healthcare system.

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