Thousands of neonates are born each year with complex congenital heart defects, such as total anomalous pulmonary venous connection combined with single ventricle physiology. This dual diagnosis with significant vessel and ventricular complexity requires alternative additional imaging to fully visualize the anatomical challenge and devise the appropriate treatment strategy for the patient.

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Prenatal diagnosis of hypoplastic aortic arch and coarctation of aorta is still challenging and remains one of the most difficult cardiac defects to diagnose. The results reveal a significant improvement of prenatal diagnosis of hypoplastic arch and coarctation of aorta. The data also shows the significant overlapping of fetal aortic isthmus z score between the infants who need the arch procedure and those who do not.