Objective. This study aimed to explore the effects of individualized nursing in patients with temporomandibular disorders (TMD). Methods. From June 2019 to April 2021, 80 patients with TMD were admitted to the First Affiliated Hospital of Wenzhou Medical University. Among them, 40 patients (control group, CG) received routine nursing and 40 patients (experimental group, EG) received individualized nursing. Functional exercise compliance, pain score, maximum mouth opening, nursing satisfaction questionnaire, self-rating anxiety scale, and self-rating depression scale were investigated. Results. From June 2019 to April 2021, 81 patients with TMD were admitted to the First Affiliated Hospital of Wenzhou Medical University. Among them, 40 patients (control group) received routine care and 41 patients (experimental group) received individual care. There were no significant differences in mouth opening and pain score between the two groups before surgery P > 0.05 , but there were significant differences in mouth opening and pain score between the two groups 3 weeks after surgery. Patients’ anxiety and depression were assessed by the SAS and SDS scores. Before nursing, the control group and experimental group P < 0.05 had no significant difference. After nursing, the score of both groups decreased P < 0.05 . However, the score was lower in the experimental group, compared to the control group P < 0.01 . Conclusion. In summary, individualized nursing can improve patients’ physical condition and reduce negative emotions and complications. In light of this, the study needs further verification by a large sample randomized controlled trial.