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Endoscopy is one of the most important methods for clinical diagnosis and treatment of digestive system diseases. It has the advantages of less pain, simple operation and shortened hospital stay after operation. 1 However, the complex structure of the endoscope contains many delicate and small components, making that the endoscope is not easy to clean. Besides, the frequent crossuse of digestive endoscopes between patients put more challenges and requirements to the disinfection of endoscope. 2 If the disinfection and sterilisation process is not strictly conducted and achieve complete sterilisation, it is easy to cause nosocomial infections and affect the medical quality and patients' safety. 3 In recent years, the incidence of nosocomial infections related to digestive

George Gaskoin in 1818, first reported by Gascoyen in 1860 and 100 years later William Bennett Bean described it in detail and coined the term: a description of the bluish colour of the cutaneous lesions and the rubbery consistency at palpation, also called Bean's syndrome (1). Up to now, around 350 cases of BRBNS with a diverse clinical presentation have been reported world-wide according to

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