No abstract

Oral route is the most commonly employed route of drug administration. Although different Route of administration are used for the delivery of drugs, oral route remain the preferred mode. The popularity of the oral route is attributed patient acceptance, ease of administration, accurate dosing, cost effective manufacturing method and generally improved shelflife of the product. Even for sustained release systems the oral route of administration has been investigated the most, because of flexibility in dosage forms design that the oral route offers. With many drugs, the basic goal of therapy is to achieve a steady-state blood level or tissue level that is therapeutically effective and nontoxicfor an extended period of time. 1-4 Bi-layer tablet concept has long been utilized to develop sustained released formulation. Such

A dissolution method was developed and UV spectrophotometry was developed for the evaluation of the dissolution of tablets containing 15 mg Noscapine .The dissolution medium 0.1 N HCl was found suitable to ensure sink conditions. USP Apparatus 2, 900 mL dissolution medium 45 minutes and 100 RPM were fixed. Dissolution profiles were generated at 10, 15, 20,   30; 45 min. Dissolution samples were analyzed with UV spectrophotometer at 213 nm. The UV method for determination of tablet was developed and validated. The method presented linearity (R2 = 0.999) in the concentration range of 1–9 μg/mL. The recoveries were good, ranging from 97.18% to 101.45%. The intraday and Interday precision results were 0.54% and 0.78% RSD, respectively. The developed dissolution test is adequate for its purpose and can be applied for the quality control of tablets. Keywords: Dissolution test; Noscapine; Tablets; UV Spectrophotometry method

Cystic fibrosis (CF) is one of the most deadly diseases of lungs that involves symptoms such as breathing difficulties, coughing and lung infection. Despite important therapeutic advances, the definitive treatment for CF remains elusive. CF is a good candidate for gene therapy because it is relatively common, lethal and monogenic and it does not have adequate treatment options. In this review article, we have reviewed gene therapy as a potential treatment option for CF. Various platforms and strategies for pulmonary gene delivery have also been discussed in detail.