Recently, transcranial direct current stimulation (tDCS) has been applied to relieve symptoms in individuals with autism spectrum disorder (ASD). In this prospective, parallel, single-blinded, randomized study, we investigate the modulation effect of three-week tDCS treatment at the left dorsal lateral prefrontal cortex (DLPFC) in children with ASD. 47 children with ASD were enrolled, and 40 (20 in each group) completed the study. The primary outcomes are Childhood Autism Rating Scale (CARS), Aberrant Behavior Checklist (ABC), and the Repetitive Behavior Scale-Revised (RBS-R). We found that children with ASD can tolerate three-week tDCS treatment with no serious adverse events detected. A within-group comparison showed that real tDCS, but not sham tDCS, can significantly reduce the scores of CARS, Children’s Sleep Habits Questionnaire (CSHQ), and general impressions in CARS (15th item). Real tDCS produced significant score reduction in the CSHQ and in CARS general impressions when compared to the effects of sham tDCS. The pilot study suggests that three-week left DLPFC tDCS is well-tolerated and may hold potential in relieving some symptoms in children with ASD.

The PM2.5 concentration model is the key to predict PM2.5 concentration. During the prediction of atmospheric PM2.5 concentration based on prediction model, the prediction model of PM2.5 concentration cannot be usually accurately described. For the PM2.5 concentration model in the same period, the dynamic characteristics of the model will change under the influence of many factors. Similarly, for different time periods, the corresponding models of PM2.5 concentration may be different, and the single model cannot play the corresponding ability to predict PM2.5 concentration. The single model leads to the decline of prediction accuracy. To improve the accuracy of PM2.5 concentration prediction in this solution, a multiple model adaptive unscented Kalman filter (MMAUKF) method is proposed in this paper. Firstly, the PM2.5 concentration data in three time periods of the day are taken as the research object, the nonlinear state space model frame of a support vector regression (SVR) method is established. Secondly, the frame of the SVR model in three time periods is combined with an adaptive unscented Kalman filter (AUKF) to predict PM2.5 concentration in the next hour, respectively. Then, the predicted value of three time periods is fused into the final predicted PM2.5 concentration by Bayesian weighting method. Finally, the proposed method is compared with the single support vector regression-adaptive unscented Kalman filter (SVR-AUKF), autoregressive model-Kalman (AR-Kalman), autoregressive model (AR) and back propagation neural network (BP). The prediction results show that the accuracy of PM2.5 concentration prediction is improved in whole time period.

Urbanization, industrialization, and regional economic integration have developed rapidly in China in recent years. Air pollution has attracted more and more attention. However, PM2.5is the main particulate matter in air pollution. Therefore, how to predict PM2.5accurately and effectively has become a concern of experts and scholars. For the problem, atmosphere PM2.5concentration prediction algorithm is proposed based on time series and interactive multiple model in this paper. PM2.5concentration is collected by using the monitor at different air quality levels. The time series models are established by historical PM2.5concentration data, which were given by the autoregressive model (AR). In the paper, three PM2.5time series models are established for three different air quality levels. Then, the three models are converted to state equation, respectively, by autoregressive integrated with Kalman filter (AR-Kalman) approaches. Besides, the proposed interactive multiple model (IMM) algorithm is, respectively, compared with autoregressive (AR) model algorithm and AR-Kalman prediction algorithm. It is turned out the proposed IMM algorithm is more accurate than the other two approaches for PM2.5prediction, and it is effective.

Due to the randomness and uncertainty in the atmospheric environment, and accompanied by a variety of unknown noise. Accurate prediction of PM2.5 concentration is very important for people to prevent injury effectively. In order to predict PM2.5 concentration more accurately in this environment, a hybrid modelling method of support vector regression and adaptive unscented Kalman filter (SVR-AUKF) is proposed to predict atmospheric PM2.5 concentration in the case of incorrect or unknown noise. Firstly, the PM2.5 concentration prediction model was established by support vector regression. Secondly, the state space framework of the model is combined with the adaptive unscented Kalman filter method to estimate the uncertain PM2.5 concentration state and noise through continuous updating when the model noise is incorrect or unknown. Finally, the proposed method is compared with SVR-UKF method, the simulation results show that the proposed method is more accurate and robust. The proposed method is compared with SVR-UKF, AR-Kalman, AR and BP methods. The simulation results show that the proposed method has higher prediction accuracy of PM2.5 concentration.