The smart grid is widely considered to be the informationization of the power grid. As an essential characteristic of the smart grid, demand response can reschedule the users' energy consumption to reduce the operating expense from expensive generators and further to defer the capacity addition in the long run. This survey comprehensively explores the four major aspects -programs, issues, approaches, and future extensions -of demand response. Specifically, we first introduce the means/tariffs that the power utility takes to incentivize users to reschedule their energy usage patterns. Then we survey the existing mathematical models and problems in the previous and current literatures, followed by the state-of-the-art approaches and solutions to address these issues. Finally, based on the above overview, we also outline the potential challenges and future research directions in the context of demand response.

H9N2 subtype influenza viruses have been detected in different species of wild birds and domestic poultry in many countries for several decades. Because these viruses are of low pathogenicity in poultry, their eradication is not a priority for animal disease control in many countries, which has allowed them to continue to evolve and spread. Here, we characterized the genetic variation, receptor-binding specificity, replication capability, and transmission in mammals of a series of H9N2 influenza viruses that were detected in live poultry markets in southern China between 2009 and 2013. Thirty-five viruses represented 17 genotypes on the basis of genomic diversity, and one specific “internal-gene-combination” predominated among the H9N2 viruses. This gene combination was also present in the H7N9 and H10N8 viruses that have infected humans in China. All of the 35 viruses preferentially bound to the human-like receptor, although two also retained the ability to bind to the avian-like receptor. Six of nine viruses tested were transmissible in ferrets by respiratory droplet; two were highly transmissible. Some H9N2 viruses readily acquired the 627K or 701N mutation in their PB2 gene upon infection of ferrets, further enhancing their virulence and transmission in mammals. Our study indicates that the widespread dissemination of H9N2 viruses poses a threat to human health not only because of the potential of these viruses to cause an influenza pandemic, but also because they can function as “vehicles” to deliver different subtypes of influenza viruses from avian species to humans.

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