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A relatively simple grain scale crystal plasticity model is developed for the third generation Ni-base disk superalloy ME3. The constitutive model embeds both microtwinning and octahedral and cube slip without explicitly modeling ' precipitates and matrix. The average size and volume fraction of ' precipitates as well as the average grain size and crystallographic orientation are incorporated to embed sub-grain microstructural effects. Additionally, microtwinning is incorporated to specify the slip system shearing rate contribution via an Orowan equation, with kinetics based on diffusional reordering. The constitutive model is calibrated to straincontrolled cyclic histories and constant load creep experimental data for two supersolvus microstructures at 704 • C and 760 • C.