Current cell‐based therapies administered after myocardial infarction (MI) show limited efficacy due to subpar cell retention in a dynamically beating heart. In particular, cardiac patches generally provide a cursory level of cell attachment due to the lack of an adequate microenvironment. From this perspective, decellularized cell‐derived ECM (CDM) is attractive in its recapitulation of a natural biophysical environment for cells. Unfortunately, its weak physical property renders it difficult to retain in its original form, limiting its full potential. Here, a novel strategy to peel CDM off from its underlying substrate is proposed. By physically stamping it onto a polyvinyl alcohol hydrogel, the resulting stretchable extracellular matrix (ECM) membrane preserves the natural microenvironment of CDM, thereby conferring a biological interface to a viscoelastic membrane. Its various mechanical and biological properties are characterized and its capacity to improve cardiomyocyte functionality is demonstrated. Finally, evidence of enhanced stem cell delivery using the stretchable ECM membrane is presented, which leads to improved cardiac remodeling in a rat MI model. A new class of material based on natural CDM is envisioned for the enhanced delivery of cells and growth factors that have a known affinity with ECM.
Background and objective: This study was conducted to establish a plan and promotion strategies for designating Worasan Garden in Jinju as a national garden.Methods: First, we examined the legal designation requirements and related regulations of national gardens through literature reviews, field investigations, and interviews regarding Suncheonman National Garden and Taehwagang National Garden, which were designated. We also conducted case studies on the organizational structure for national garden designation in terms of administration; spatial composition, major plant materials, and facilities in terms of garden planning; operating hours, management/operation organizations, and other garden characteristics in terms of operation.Results: The concept and designation requirements of national gardens are set by law. Worasan Garden is located in the gentle mountain area of Worasan, where forests damaged by forest fires in the past were restored by the voluntary effort of citizens, and is connected to four villages with the rural landscape. By converging the climate and vegetation of the southern region with the mountain topography, rural culture, and historical resources, Worasan Garden can be planned as a national garden with differentiation and identity. To effectively promote national garden designation, it is first necessary to hold garden expansion campaigns such as citizen publicity and garden education to obtain citizens' positive awareness, support, and participation. The garden hinterland must be designated as a green district to prevent sprawl. Cooperation with local residents, experts, and related organizations, as well as training in human resources, are also needed. Events such as a garden expo are required to improve the image. There must also be garden publicity and marketing as well as regional tourism. It is also necessary to establish garden-related ordinances and integrated plans.Conclusion: The Jinju government must first register Worasan Garden as a local garden. It is necessary to establish a creation plan and implementation strategies to meet the requirements for national garden designation from the point where preparations are made for a local garden. The garden must be planned and designed so that it has an identity as a national garden and is differentiated from others by combining the symbol of forest restoration in Worasan Mountain, the characteristics of the forest landscape in the southern region, and the image of urban countryside villages that represent the historical and cultural resources of Jinju. The implementation strategies require a bottom-up resident participation plan by obtaining positive awareness, support, and participation of citizens for national gardens, establishing laws and systems, and performing administrative or financial tasks.
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