Hepatitis B virus (HBV) infection remains a major cause of liver cirrhosis in China. 1 Every year, approximately 3% of cases of compensated cirrhosis progress to decompensated cirrhosis, which is characterized by various complications and an estimated 5-year mortality rate of up to 85%. 2-4 The identification of accurate, objective, and user-friendly prognostic markers is essential to guide management strategies for patients with HBV-associated decompensated cirrhosis (HBV-DeCi). There is increasing evidence that the hematological parameters, such as neutrophil-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, red cell distribution width, and mean platelet volume, are reliable inflammatory markers and prognostic indices in a variety of medical conditions like cerebral hemorrhage, 5,6 major cardiac events, 7,8 brain infarct, 9,10 cancers, 11 sepsis, and infectious pathologies. 12 In recent years, a strong interest has been drawn to these indices, given that they may provide independent information on pathophysiology, risk stratification, and optimal management. Their low-cost and consequent wide and easy availability in daily clinical practice have made them very

The Clinical and Laboratory Standards Institute (CLSI) C24-ED4 guidelines 1 recommend the implementation of risk-based statistical quality control (SQC). It is recommended to design a limited interval SQC for continuous analysis processes, that is, to implement a quality control event before and after testing a limited group of samples, and the number of samples in this group is the run size, the number of quality control (QC) events in the continuous analytical process is the QC frequency. However, many SQC design tools fail to clearly provide the SQC frequency selection and design parameters required for continuous analysis process. Westgard took

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