Ab ismuth(III)b romide-catalysedd irect substitution of benzyla lcohols with arylsulfonylmethyl isocyanides affords sulfinates under mild acidic conditions.A nu nforeseen reversed reactivity was observed in this highly selectivef ormationo f sulfinates instead of the formation of the usually favoured sulfones. Cytotoxicity tests (in vitro)i ndicated that the sulfinates exhibit antibiotic activity against ah uman leukaemia cell line HL-60, which would widen the structural diversity of this antitumour target and confirm the perspectives of further investigations.

No abstract

No abstract

No abstract

A copper-catalyzed formation of C-N/N-N bonds using Nphenylbenzamidines with aryl nitriles has been developed and affords a route to 1,3,5-trisubstituted 1H-1,2,4-triazoles in moderate to excellent yields. The method is operationally simple and environmentally benign with a large substrate scope available and represents an economical path for numerous C-N/N-N bond formations.