To show the traditional Chinese painting and the spiritual culture of universities, highlight the artistic accumulation and cultural heritage, analyze the value and significance of digitalizing the Museum of Ancient High-Imitative Calligraphy and Painting, Qingdao Agricultural University (QAU) is regarded as the research object. The design principles of the digital museum are clarified by understanding the specific user needs, and the 3DS Max is utilized to develop a roaming system for the Museum of Ancient High-Imitative Calligraphy and Painting of QAU through Unity3d, a Virtual Reality (VR) software platform. Besides, the perspective control, collision detection of virtual characters and scenes, and control of pop-up information display windows are realized to achieve the interactive design of users and the QAU digital museum system. Finally, from the four aspects of resource content, information presentation, resource presentation, and learning effect, a comprehensive evaluation is conducted. The research results show that more than 80% of people think that the content satisfaction of virtual system resources is high, which is more scientific and accurate; more than 65% think that the information is presented better, and 87% think that the system is open enough; in addition, nearly one-third of the visitors believe that using the system can initiate their interest and motivation in learning. This shows that the learning and cultural communication effects of the virtual system are more obvious. This system realizes the objective of disseminating traditional classic art culture and values by new technical means, which has reference significance for research in other fields. INDEX TERMS virtual roaming; high-imitative calligraphy and painting; digital museum; digital system