Background This study aims to examine the prospective association of inflammatory bowel disease (IBD) with long-term risk of overall, site-specific cancer and cancer-specific mortality in middle-aged and older people. Methods The study included participants free of any cancer at baseline from the UK Biobank, with IBD patients as an exposure group and non-IBD patients as a reference group. Primary outcome was the incidence of overall cancer and cancer-specific mortality. Secondary outcomes included site-specific cancers and types of digestive cancers. Cox proportional hazard model was used to investigate the associated risk of incident malignancies and related mortality. Results Among 455 927 participants, 5142 were diagnosed with IBD (3258 ulcerative colitis [UC]; 1449 Crohn’s disease [CD]; others unspecified). During a median of 12.2-year follow-up, 890 cases of incident cancer were identified in IBD patients (15.74 per 1000 person years) compared with 63 675 cases in reference individuals (12.46 per 1000 person years). Of these cases, 220 and 12 838 cancer-specific deaths occurred in IBD and non-IBD groups. Compared with non-IBD participants, the adjusted hazard ratio (AHR) for overall cancer and cancer-specific mortality was 1.17 (95% CI, 1.09-1.25) and 1.26 (95% CI, 1.18-1.35) among IBD patients, with an AHR of 1.15 (95% CI, 1.02-1.31) and 1.38 (95% CI, 1.08-1.75) in UC and 1.15 (95% CI, 1.06-1.25) and 1.25 (95% CI, 1.06-1.49) in CD, respectively. Specifically, increased risk of digestive (1.33; 95% CI, 1.12-1.57), nonmelanoma (1.25; 95% CI, 1.11-1.41), and male genital (1.29; 95% CI, 1.09-1.52) cancers was observed in IBD patients. Conclusions Compared with non-IBD, IBD may be associated with an increased risk of overall cancer and cancer-specific mortality, particularly digestive cancers, nonmelanoma and male genital cancers.

Background and Aims: Using grafts from donors after cardiac death (DCD) influence the risk of acute kidney injury (AKI) after liver transplantation (LT). The goal of this study is to develop a novel prediction model that quantifies the impact of each risk factor on AKI after transplantation using DCD grafts.Methods: Total of 132 patients undergoing LT using DCD grafts were evaluated retrospectively to develop a prediction model using the Cox proportional hazards regression model. The independent validation cohort included 112 patients recruited prospectively in the same institution. Results: Overall, 103 (42.2%) of the recipients developed AKI. A prediction score model included five risk factors leading to a range of -2 to 8 score points was establishment. The predicted probability of AKI by the Model for End-Stage Liver Disease (MELD) score≥15 alone was 43.9% rising to 85.3% when combined with cold ischemia time (CIT) ≥ 7 hours. Excessive red blood cell (RBC) transfusions during operation also attribute to AKI. Surprisingly, a mild elevate AST pre-transplant was negative with the AKI, while mechanical ventilation ≥ 40 hours was associate with AKI after LT. Three risk classes were defined based on the risk of AKI: high (30%), medium (11-29%), and low (10%). Model fits were adequate in both derivation (P=0.3185) and validation cohorts (P=0.3247).Conclusion: MELD score and CIT were the key determinants of post-LT AKI using DCD grafts. Improved organ preservation techniques and other strategies reducing the IRI may lower the risk of AKI.