Schizophrenia, a fare mental disorder that affects up to 1% of the population among the world, is a significant topic being researched in recent years. Some researchers have found a gene called Neuregulin-1(NRG1) that may relate to schizophrenia. However, the role of NRG1 in schizophrenia has not yet been well explained. Therefore, this research essay collects information on NRG1 and schizophrenia and then analyzes the effects of NRG1 on neurons, such as excitatory/inhibitory neurotransmission. This essay would also focus on the treatments of schizophrenia, including pharmacological therapy and CRISPR-based evaluation of schizophrenia. In this case, the essay would research on the relationship between NRG1 and schizophrenia. As research shows, the NRG1 may negatively lead to schizophrenia genetically. The interaction between NRG1 and other substances in our brain, such as NMDAR or GABA released by interneurons. Treatments for schizophrenia could deal with this disease through two main pathways; nonpharmacological therapy and pharmacological therapy could help with easing the patient by releasing the symptoms. CRISPR, however, could deal with schizophrenia directly by editing a certain section of DNA. So people could either release the symptoms causedthe by the interaction of NRG1 with other receptors, or edit DNA information by CRISPR.