The insecticidal and repellent activities of the essential oil extracted from Zingiber purpureum Roscoe rhizomes were evaluated against Tribolium castaneum (Herbst) and Lasioderma serricorne (L.) adults. During our screening program for agrochemicals from Chinese medicinal herbs and wild plants, the essential oil of Z. purpureum rhizomes was found to possess strong contact toxicity against T. castaneum and L. serricorne adults, with LD50 values of 39.0 and 16.3 µg per adult, respectively, and also showed strong fumigant toxicity against the two grain storage insects with LC50 values of 13.6 and 9.3 mg/liter of air, respectively. The essential oil obtained by hydrodistillation was investigated by gas chromatography-mass spectrometry. The main components of the essential oil were identified to be sabinene (48.1%), terpinen-4-ol (25.1%), and γ-terpinene (6.7%), followed by α-terpinene (4.3%), β-thujene (3.4%), and α-phellandrene (2.7%). Sabinene, terpinen-4-ol, and γ-terpinene were separated and purified by silica gel column chromatography and preparative thin-layer chromatography. Terpinen-4-ol showed the strongest contact toxicity against T. castaneum and L. serricorne (LD50=19.7 and 5.4 µg per adult, respectively) and also the strongest fumigant toxicity against T. castaneum and L. serricorne (LC50=3.7 and 1.3 mg/liter of air, respectively). Otherwise, sabinene and terpinen-4-ol were strongly repellent against T. castaneum as well as the essential oil, while γ-terpinene exhibited weaker repellency against T. castaneum compared with the positive control, DEET (N, N-diethyl-3-methylbenzamide). Moreover, only the essential oil exhibited strong repellency against L. serricorne, the three compounds exhibited weaker repellency against L. serricorne relative to DEET.

Changes in extreme precipitation differ among regions (e.g., dry and wet regions), causing different adverse effects on human life, social economy, and natural ecosystems on a warming planet. In this study, we use the 95th percentile‐based threshold to define extreme precipitation. The spatiotemporal changes in extreme precipitation and temperature‐extreme precipitation scaling relationship between dry and wet regions of mainland China during 1961‐2014 are analyzed using two gridded data sets of precipitation and temperature observations. Extreme precipitation increased faster in dry regions (3.9% frequency and 2.8% relative intensity per decade) compared to wet regions (2.5% frequency and 2.1% relative intensity per decade) over the past 54 years. Despite the negative regression relationship between mean precipitation and temperature in wet regions, extreme precipitation has a positive relationship with temperature. The regression coefficient in relative intensity against temperature change is 6% per °C in wet regions. The frequency increases significantly (p < 0.01) faster as temperature increases in wet regions (11.1% per °C) compared with dry regions (6.9% per °C). These results suggest that precipitation extremes increase for both dry and wet regions, and faster trends are observed in dry regions. However, the same magnitude of warming causes more extreme precipitation in wet regions. Therefore, more extreme precipitation in future may raise the risk of flooding in both dry and wet regions, particularly for wet regions, due to the stronger relative intensity and faster increases against warming.

Abstract:A new compound and seven known compounds were isolated from Murraya tetramera Huang for the first time, and they were identified with NMR and MS spectral analysis. It was confirmed that the new compound was 10-methoxy-7-methyl-2H-benzo[g]chromen-2-one (3) and the others were β-eudesmol (1), trans-3β-(1-hydroxy-1-methylethyl)-8aβ-methyl-5-methylenedecalin-2-one (2), 5,7-dimethoxy-8-[(Z)-3'-methylbutan-1',3'-dienyl]coumarin (4), 7-geranyloxy-6-methoxycoumarin (5), 5,7-dimethoxy-8-(3-methyl-2-oxo-butyl)coumarin (6), murrangatin acetate (7) and toddalenone (8). Furthermore, the cytotoxic activity against human lung adenocarcinoma (A549), human hepatocellular carcinoma cells (SMMC-7721), human bladder tumor cells (EJ), human cervical carcinoma cells (HeLa), and human B-lineage acute lymphoblastic leukemia 1 cells (BALL-1) was evaluated for all compounds. It was found that five of them displayed various degrees of OPEN ACCESSMolecules 2014, 19 13226 cytotoxicity against different testing targets. Compound 1 showed significant cytotoxic activity against the five cell lines (A549, SMMC-7721, EJ, Hela and BALL-1). Compounds 2 and 5 showed significant cytotoxicity against three cell lines (A549, SMMC-7721 and BALL-1). Compound 4 showed significant cytotoxicity against three cell lines (A549, EJ and BALL-1). However, compound 3 only showed fair cytotoxicity against the BALL-1 cell line. The structure-active relationships were investigated as well. These active compounds might be potential lead compounds for the treatment of cancer.

LETTERVariations in start date, end date, frequency and intensity of yearly temperature extremes across China during the period Abstract Frequent temperature extremes due to climate change have had serious effects on human society and the natural environment. Using a 0.25°×0.25°gridded Tmax (daily maximum temperature) and Tmin (daily minimum temperature) data set and 12 global climate models simulations from the sixth phase of the Coupled Model Intercomparison Project (CMIP6), we investigated variations in yearly temperature extremes in China during the past five decades with respect to four characteristics, namely, their start date, end date, frequency, and intensity. Results showed that the occurrence of nighttime extremes (the cold nights and warm nights) responded strongly to climate change. For 1961-2017, cold extremes started later (3.25 d/decade) and ended earlier (−4.58 d/decade), with decreased frequency (−6.56 d/decade), especially for cold nights, and weakened intensity (0.14°C/ decade). In the same period, warm extremes started earlier (−3.43 d/decade) and ended later (3.15 d/ decade) with increased frequency (6.79 d/decade), especially for warm nights, and enhanced intensity (0.09°C/decade). The spatial pattern of the variations was complex with anomalous regions. Multimodel ensembles (MMEs) from CMIP6 agreed well with observations regarding the average trends of temperature extremes over China, although detailed changes in spatial pattern were not captured adequately. The hazards of temperature extremes deserve close attention in the future due to the complex changes likely to occur across China for various characteristics of these temperature extremes under conditions of climate change.

Soft corals are common marine organisms that inhabit tropical and subtropical oceans. They are shown to be rich source of secondary metabolites with biological activities. In this work, soft corals from two geographical locations were investigated using 1H-NMR spectroscopy coupled with multivariate statistical analysis at the metabolic level. A partial least-squares discriminant analysis showed clear separation among extracts of soft corals grown in Sanya Bay and Weizhou Island. The specific markers that contributed to discrimination between soft corals in two origins belonged to terpenes, sterols and N-containing compounds. The satisfied precision of classification obtained indicates this approach using combined 1H-NMR and chemometrics is effective to discriminate soft corals collected in different geographical locations. The results revealed that metabolites of soft corals evidently depended on living environmental condition, which would provide valuable information for further relevant coastal marine environment evaluation.