Abstract. Intracranial chondrosarcoma is a rare malignant cartilage-forming tumor, with only a small number of cases in the posterior cranial fossa reported previously. The present study reports the case of a 40-year-old male patient who was admitted to Tianjin Huanhu Hospital with a progressive headache and dizziness that had lasted for 2 years. Physical and neurological examinations were normal. Radiography of the skull identified an opaque lesion in the left frontal region of the brain. Cranial computed tomography and magnetic resonance imaging revealed a lesion with calcification and homogenous contrast enhancement in the left frontal region. Subsequently, the patient underwent bicoronal craniotomy and gross total resection of the tumor. Pathological examination confirmed the diagnosis of classical intracranial chondrosarcoma. The patient was discharged 10 days after surgery, with no neurological deficit. One month after initial discharge, the patient underwent γ-knife treatment. A follow-up examination 9 months after surgery revealed that the patient was still alive and had returned to work, with no obvious symptoms or evidence of recurrence.

Craniopharyngioma is one of the most challenging issues for neurosurgeons as a brain tumor. Among the approaches of neurosurgery, in comparison to craniotomy, the endoscopic endonasal approach (EEA) has risen in popularity over the last two decades; unruptured intracranial aneurysms are relatively commonly found in the general population. The EEA as a new paradigm in the treatment of aneurysm has been reported to successfully clip dozens of cases of intracranial aneurysm. However, when reviewing the domestic and foreign literature, it appeared that cases of craniopharyngioma complicated with intracranial aneurysm purely treated by EEA have not been reported so far. In the present study, the published literature regarding endoscopic endonasal surgery for craniopharyngioma and intracranial aneurysms was reviewed, accompanied with a case of craniopharyngioma complicated with intracranial aneurysm, both of which were simultaneously treated by EEA.