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Compression elasticity of glucagon amyloid fibrils in the transverse direction was investigated by a nanoindentation approach based on atomic force microscopy (AFM). With force-volume mapping, we obtained the correlations between radially applied force and compression of amyloid fibrils, from which the radial compressive elasticity can be deduced. The estimated elastic modulus at three typical locations of fibrils varied from (0.72±0.80) GPa to (1.26±0.62) GPa under small external forces, implying the structural heterogeneity of different fibrils. amyloid fibrils, nanoindentation, AFM, elastic modulus Citation:Zhou X F, Cui C Y, Zhang J H, et al. Nanomechanics of individual amyloid fibrils using atomic force microscopy.

The polarizabilities of DNA in transverse direction and CdSe semiconductor quantum dots (QDs) deposited on mica surface are compared by means of electrostatic force microscopy (EFM). We observe clear EFM-phase shift over CdSe QDs, while no obvious signal on DNA is detected, suggesting that DNA molecules is an electrical insulator.