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Adverse Drug Reactions (ADRs) have become a serious health problem and even a leading cause of death in the United States. Pre‐marketing clinical trials and traditional post‐marketing surveillance using voluntary and spontaneous report systems are insufficient for ADR detection. On the other hand, online health forums provide valuable evidences in a large scale and in a timely fashion through the active participation of patients, caregivers, and doctors. In this article, we present patient‐centered and experience‐aware mining framework for effective ADR discovery using online health forum data. Our experimental evaluation with both an official ADR knowledge base and human‐annotated ground truth verifies the effectiveness of the proposed method for ADR discovery.

Adverse drug events (ADEs) are a serious health problem that can be life-threatening. While a lot of studies have been performed on detect correlation between a drug and an AE, limited studies have been conducted on personalized ADE risk prediction. Among treatment alternatives, avoiding the drug that has high likelihood of causing severe AE can help physicians to provide safer treatment to patients. Existing work on personalized ADE risk prediction uses the information obtained in the current medical visit. However, on the other hand, medical history reveals each patients unique characteristics and comprehensive medical information. The goal of this study is to assess personalized ADE risks that a target drug may induce on a target patient, based on patient medical history recorded in claims codes, which provide information about diagnosis, drugs taken, related medical supplies besides billing information. We developed a HTNNR model (Hierarchical Time-aware Neural Network for ADE Risk) that capture characteristics of claim codes and their relationship. The empirical evaluation show that the proposed HTNNR model substantially outperforms the comparison methods, especially for rare drugs.

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