A quad-band circularly-polarized antenna, for applications of a global navigation satellite system (GNSS), 5G, and WIFI-6E, is designed, fabricated, and measured. The proposed antenna is formed by an L-shaped radiator, a rectangular frame ground with an L-shaped stub, and a rectangular strip at the opposite corner. The microstrip antenna can generate four frequency bands, covering WIFI-6E (5925–7125 MHz), 5G n77 (3300–4200 MHz), n78 (3300–3800 MHz), and the GNSS bands. This antenna generates right hand circular polarization (RHCP) waves in the low frequency band (0.95–2.11 GHz), covering GPS, BDS, GLONASS, and GALILEO applications. Moreover, an L-shaped aperture and three rectangular slits are cut on the ground to broaden the axial-ratio bandwidth at the upper band. A prototype is fabricated and measured to verify the performance of this design. It is shown that the agreement between the simulation and measurement is satisfactorily good. The measured −10 dB bandwidths for each band are 75.8% (0.95–2.11 GHz), 55.8% (3.05–5.39 GHz), 39.9% (5.84–8.19 GHz) and 10.3% (9.14–10.68 GHz), respectively. While the measured 3 dB axial-ratio bandwidths are 59.4% (1.16–2.14 GHz), 35.8% (3.23–4.64 GHz), 8.4% (5.70–6.20 GHz), and 2.6% (7.51–7.71 GHz), the measured gains are 4.56, 2.28, 4.26, and 4.30 dBi at 1.5 GHz, 3.8 GHz, 6 GHz, and 7.6 GHz, respectively.