Background: Inappropriate prescribing of antibiotics for acute respiratory infections at the primary care level represents the major source of antibiotic misuse in healthcare, and is a major driver for antimicrobial resistance worldwide. In this study we will develop, pilot and evaluate the effectiveness of a comprehensive antibiotic stewardship programme in China's primary care hospitals to reduce inappropriate prescribing of antibiotics for acute respiratory infections among all ages.Methods: We will use a parallel-group, cluster-randomised, controlled, superiority trial with blinded outcome evaluation but unblinded treatment (providers and patients). We will randomise 34 primary care hospitals from two counties within Guangdong province into the intervention and control arm (1:1 overall ratio) stratified by county (8:9 within-county ratio). In the control arm, antibiotic prescribing and management will continue through usual care. In the intervention arm, we will implement an antibiotic stewardship programme targeting family physicians and patients/caregivers. The family physician components include: (1) training using new operational guidelines, (2) improved management and peer-review of antibiotic prescribing, (3) improved electronic medical records and smart phone app facilitation. The patient/ caregiver component involves patient education via family physicians, leaflets and videos. The primary outcome is the proportion of prescriptions for acute respiratory infections (excluding pneumonia) that contain any antibiotic(s). Secondary outcomes will address how frequently specific classes of antibiotics are prescribed, how frequently key non-antibiotic alternatives are prescribed and the costs of consultations. We will conduct a qualitative process evaluation to explore operational questions regarding acceptability, cultural appropriateness and burden of technology use, as well as a cost-effectiveness analysis and a long-term benefit evaluation. The duration of the intervention will be 12 months, with another 24 months' post-trial long-term follow-up.(Continued on next page)

With the wide application of artificial intelligence and big data technology in the medical field, the problems of high cost and low efficiency of traditional pharmacy management were becoming more and more obvious. Therefore, this paper proposed to use data mining technology to design and develop the dispensing process and equipment of intelligent pharmacy. Firstly, it summarized the existing data mining technology and association rule methods and expounded its application value in the related fields. Secondly, the data standard and integration platform of dispensing in intelligent pharmacy were established. Web service technology was used to design the interactive interface and call it to the intelligent device of pharmacy. Finally, an intelligent pharmacy management system based on association rule mining was constructed through the data mining of intelligent pharmacy equipment, in order to improve the intelligence and informatization of modern pharmacy management. For the emergency dispensing process of intelligent equipment failure, data mining was used to optimize the intelligent pharmacy equipment and dispensing process and change the pharmacy management from traditional prescription to patient drug treatment, so as to improve the dispensing efficiency of intelligent pharmacy equipment. Through the systematic test and analysis, the results showed that through the real-time risk prevention and control, the formula accuracy and operation speed of the intelligent dispensing machine were improved and the dispensing time was shortened. Through intelligent drug delivery, the unreasonable drug use of patients was reduced, the safety and effectiveness of clinical drug use were ensured, and the contradiction between doctors and patients was reduced. This study can not only optimize the medical experience of patients and provide patients with more high-quality and humanized pharmaceutical technical services but also provide some support for the intelligent management of modern hospitals.

Objective: To explore the ideas and methods of clinical pharmacists regarding drug therapy for children with Kawasaki disease.Methods: By participating in a whole drug treatment process for a child with Kawasaki disease, the rationality of the drug treatment plan was analyzed, pharmaceutical care was provided for the child, and a pharmaceutical care model suited to this child was developed.Results: After treatment, the child was discharged from the hospital, and all signs and major inflammatory indicators returned to normal. The child's parents were instructed to bring medication, visit regularly, and adjust medication. Conclusion:Through the entire process of pharmaceutical care, clinical pharmacists are able to identify and resolve drug treatment-related issues in a timely manner, and also make suggestions on rational drug use, which can improve the safety and compliance of drug use in children and the quality of clinical drug treatment.