Forward and reverse 18 O labeling are integrated with solution isoelectric focusing and capillary LCtandem mass spectrometry to evaluate a new strategy for quantitative proteomics, and to study abundance changes in mitochondrial proteins associated with drug resistance in MCF-7 human cancer cells. Galectin-3 binding protein, which is involved in apoptosis, was detected only in the resistant cell line, as a result of reverse labeling. Among 278 proteins identified, twelve were detected with abundances altered at least 2-fold.

High-color purity organic emitters with a simultaneous combination of aggregation-induced emission (AIE) and thermally activated delayed fluorescence (TADF) characteristics are in great demand due to their excellent comprehensive performances toward efficient organic light-emitting diodes (OLEDs). In this work, two D−π–A-structure emitters, ICz-DPS and ICz-BP, exhibiting AIE and TADF properties were developed, and both the emitters have narrow singlet (S1)–triplet (T1) splitting (ΔE ST) and excellent photoluminescence (PL) quantum yields (ΦPL), derived from the distorted configurations and weak intra/intermolecular interactions, suppressing exciton annihilation and concentration quenching. Their doped OLEDs based on ICz-BP provide an excellent electroluminescence external quantum efficiency (ηext) and current efficiency (ηC) of 17.7% and 44.8 cd A–1, respectively, with an ηext roll-off of 2.9%. Their nondoped OLEDs based on ICz-DPS afford high efficiencies of 11.7% and 30.1 cd A–1, with pure-blue emission with Commission Internationale de l’Éclairage (CIE) coordinates of (0.15, 0.08) and a low roll-off of 6.0%. This work also shows a strategy for designing AIE–TADF molecules by rational use of steric hindrance and weak inter/intramolecular interactions to realize high ΦPL values, fast reverse intersystem crossing process, and reduced nonradiative transition process properties, which may open the way toward highly efficient and small-efficiency roll-off devices.

F–π interactions play a key role in improving the electron mobility of fluorinated electron acceptors for non-fullerene OSCs.

Investigating three novel Ge-based high-performance bipolar hosts for deep blue phosphorescent OLEDs by multiscale simulation of charge transport.

We proposed two novel quad-rotor-shaped non-fullerene electron acceptor materials, which exhibit much better optoelectronic properties than that of the widely used non-fullerene acceptor ITIC.