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high-harmonic generation (HHG), the multiphoton absorption (MPA) upconversion lasing is an alternative approach to produce short wavelength laser sources. The MPA upconversion lasing is a typical higher-order nonlinear optical process in which the short wavelength lasing was realized through the stimulated emission between the up and low energy level; here, the population inversion was constructed by means of simultaneous MPA. [2] Comparing with traditional HHG techniques, the MPA upconversion lasing does not require stringent phase-matching requirements. [3,4] Hence, the tuning range of pumping light for MPA upconversion laser can be extended significantly. In addition, the MPA upconversion laser has a deep penetration depth compared with the conversion laser, which expands a great application value in biological imaging, [5] laser tomography, [6] photodynamic therapy, [7] and others. Ever since He et al. firstly demonstrated three-photon excited stimulated emission in organic dyes solution, [2] two-or three-photon absorption upconversion lasing has also been revealed in other organic dyes, [8,9] semiconductor quantum dots, [10] and perovskite nanocrystals. [11] However, the intrinsic liquid properties of organic dyes and the poor antiradiation ability of perovskite nanocrystals will be their bottleneck to practical applications drastically. Semiconductor crystal may be more suitable for such application due to its large damage resistance threshold and high optical gain. [12][13][14][15] Although two-and three-photon absorption upconversion lasing have been achieved in semiconductors such as ZnO, [16,17] only a few report on the above four-photon excited lasing to the best of our knowledge. [18] In order to realize higher-order MPA upconversion lasing, special attention has been paid to synthesize materials with large MPA cross-sections and large optical gain. [19] On the other hand, the MPA upconversion lasing is a typical high-order nonlinear photon-matter interaction process, which dramatically depends on the optical field intensity. Recently, the high-order nonlinear optical effect has been observed in high Q-factor microcavity. [20] It is anticipated that the manipulation of optical field through the construction of microcavity for the exciting light may be an alternative technique to achieve high-order MPA upconversion lasing. However, the short spatial gain length l g deduced from femtosecond (fs) laser pulse duration τ (l g = c·τ) will set a requirement forThe upconversion lasing through simultaneous multiphoton absorption (MPA) is a high-order nonlinear optical process, which enables many critical applications in the fluorescence imaging probe, laser tomography, and photodynamic therapy. Herein, the upconversion lasing from microwires via simultaneous six-photon absorption at room temperature is first realized. Moreover, the lasing peak and third-harmonic generation peak of pumping light are observed concurrently, while the temperature-dependent spectrum elucidates the essential distinction between each...

The realization of a one-dimensional (1D) random laser (RL) by using artificially fabricated scatterers is reported in this letter, and the lasing characteristic has also been investigated comprehensively. The manipulation of the lasing mode in the 1D microwire (MW) RL can be achieved through micro-pits prepared by the laser-ablation technique. Well-defined sharp lasing peaks were realized based on the coherence feedback process in the 1D optical waveguide. The near- and far-field images exhibit excellent spatial intensity distribution, and the stability of lasing modes has also been investigated. Our results represent a novel method towards the development of a manipulated-RL, which will highlight the application of disordered systems in optoelectronic devices.

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BackgroundPyroptosis and prostate cancer (PCa) are closely related. The role of pyroptosis-related long non-coding RNAs (lncRNAs) (PRLs) in PCa remains elusive. This study aimed to explore the relationship between PRL and PCa prognosis.MethodsGene expression and clinical signatures were obtained from The Cancer Genome Atlas and Gene Expression Omnibus databases. A PRL risk prediction model was established by survival random forest analysis and least absolute shrinkage and selection operator regression. Functional enrichment, immune status, immune checkpoints, genetic mutations, and drug susceptibility analyses related to risk scores were performed by the single-sample gene set enrichment analysis, gene set variation analysis, and copy number variation analysis. PRL expression was verified in PCa cells. Cell Counting Kit-8, 5-ethynyl-2′-deoxyuridine, wound healing, transwell, and Western blotting assay were used to detect the proliferation, migration, invasion, and pyroptosis of PCa cells, respectively.ResultsPrognostic features based on six PRL (AC129507.1, AC005253.1, AC127502.2, AC068580.3, LIMD1-AS1, and LINC01852) were constructed, and patients in the high-score group had a worse prognosis than those in the low-score group. This feature was determined to be independent by Cox regression analysis, and the area under the curve of the 1-, 3-, and 5-year receiver operating characteristic curves in the testing cohort was 1, 0.93, and 0.92, respectively. Moreover, the external cohort validation confirmed the robustness of the PRL risk prediction model. There was a clear distinction between the immune status of the two groups. The expression of multiple immune checkpoints was also reduced in the high-score group. Gene mutation proportion in the high-score group increased, and the sensitivity to drugs increased significantly. Six PRLs were upregulated in PCa cells. Silencing of AC005253.1 inhibited cell proliferation, migration, and invasion in DU145 and PC-3 cells. Moreover, silencing of AC005253.1 promoted pyroptosis and inflammasome AIM2 expression.ConclusionsOverall, we constructed a prognostic model of PCa with six PRLs and identified their expression in PCa cells. The experimental verification showed that AC005253.1 could affect the proliferation, migration, and invasion abilities of PCa cells. Meanwhile, AC005253.1 may play an important role in PCa by affecting pyroptosis through the AIM2 inflammasome. This result requires further research for verification.