Recently we have created a new open‐source technology called BodyLight.js which combines the current standard for web‐based applications including Web‐Assembly for fast computation of mathematical models, web components for building independent transferable objects, and WebGL for involving 3D graphic [1, 2]. We have published methodology and implementation of several models of the cardiovascular system [3]. We have been creating graphical components in 2D and recently in 3D which can be used as animations in simulation application. There are numerous steps involved when going from an idea to a finished project. In this contribution we describe the workflow going from concept to mathematical model and computer graphics to an educational simulation application. This workflow is presented by building a simulation game of hemodynamics of the cardiovascular system. Each step of the workflow can be executed by different domain expert. Physiologist designs concept, mathematician writes and implements mathematical models and executable model simulation programs, graphical designer produces graphical objects based on design concepts which can be animated in simulation programs, and software engineer maintains the system. However, all these professionals need to be able to understand each other and work together. Physiologists must be able to grasp the physiological significance and to tell mathematician how to formalize the problem. Mathematicians and software engineers need to understand physiology in order to produce plausible and verifiable model simulation application. Computer graphics designers must be skilled in programming as they need to produce animated objects that can be used in simulation applications. This connection of expertise is crucial, and was already proposed e.g. by N. Wiener in his works about Cybernetics [4]. We demonstrate that such creative connection of individuals with combined and shared expertise can produce high quality educational materials. Support or Funding Information MPO TRIO FV20628, MPO TRIO FV30195 Collaborative workflow designing simulator of pressure‐volume loop cycle of hemodynamics model using Bodylight.js software tools. Development of In-Browser Simulators for Medical Education: Introduction of a Novel Software ToolchainJŠilarJ Med Internet Res217e14160 https://bodylight.physiome.cz/-Bodylight.jsframeworkLumped models of the cardiovascular system of various complexityFilipJežekBiocybernetics and Biomedical Engineering374666678Cybernetics or control and communication in the animal and the machineNorbertWienerThe M.I.T. Press