This study demonstrates the feasibility of using (90)Y-DOTA-cT84.66 for antibody-guided radiation therapy. Immunogenicity of the DOTA-conjugated cT84.66 antibody was not appreciably greater than that observed with (90)Y-DTPA-cT84.66 in previous trials. Dose-limiting hematopoietic toxicity with (90)Y-DOTA-cT84.66 decreased with Ca-DTPA infusions post-therapy and appears to be comparable to previously published results for (90)Y-DTPA-cT84.66. The highest antibody uptake and tumor doses were to small nodal lesions, which supports the predictions from preclinical and clinical data that RIT may be best applied in the minimal tumor burden setting.

The visible-light-driven CO 2 reduction efficiency is largely restrained by the negative photoabsorption and high recombination rate of electron−hole pairs. It is an effective method to increase the efficiency of CO 2 photoreduction by doping alkali metal elements to engineer the electronic properties of the catalyst. Here, we report a new study on the potassium-doped g-C 3 N 4 (K-CN) being used for CO 2 reduction irradiated by visible light. DFT calculations and XPS tests show that the potassium doping is interlayer doping, changing the electronic structure of g-C 3 N 4 . The higher I D /I G value indicates more structural distortion and defects caused by K doping. K-CNs have enhanced visible-light absorption, and PL spectra demonstrate that the introduction of potassium advances the separation and transmission of photoexcited charge carriers, further confirmed by transient photocurrent response experiment. Under visible light, K-CN-7 achieved efficient CO 2 reduction without any noble metal as a cocatalyst, with CO formation rates of 8.7 μmol g −1 h −1 , which is 25 times that of ordinary g-C 3 N 4 . Our work further validates the importance of inhibiting e − /h + recombination in improving solar energy conversion efficiency while also bringing hope for efficient solar fuel production using g-C 3 N 4 . KEYWORDS: g-C 3 N 4 , CO 2 photoreduction, potassium doping, first-principles calculations, photocatalysis

Purpose: To develop a phased-array coil-compatible, fast three-point Dixon (TPD) technique, and compare its performance in T2-weighted spine imaging with that of the standard chemical shift selective (CHESS) fat suppression technique. Materials and Methods:We acquired T2-weighted spine images of 27 patients using essentially identical scanning parameters with the fast TPD technique and standard fast spin echo (FSE) with CHESS fat suppression. A phasedarray coil-compatible image reconstruction algorithm was developed to generate separate water and fat images from the data acquired with the fast TPD technique. Three neuroradiologists independently scored the images from the two different techniques for uniformity of fat suppression and lesion conspicuity using a four-point system (1 ϭ poor, 2 ϭ fair, 3 ϭ good, 4 ϭ best). Results:The reviewers' mean scores were 3.2 and 2.1 for the uniformity of fat suppression, and 3.0 and 2.0 for the lesion conspicuity for the fast TPD and the CHESS fat suppression techniques, respectively. The fast TPD technique was statistically superior to the CHESS technique at P Ͻ 0.0005. Conclusion:The fast TPD technique provides superior fat suppression and lesion conspicuity, and potentially can be used as an alternative to T2-weighted imaging of the spine. FAST SPIN-ECHO (FSE, or rapid acquisition with relaxation enhancement (RARE)) (1) T2-weighted magnetic resonance imaging (MRI) with chemical shift selective (CHESS) (2,3) fat suppression is currently an essential component of routine MRI of the spine. Despite the widespread use and success of this technique, however, the quality of its fat suppression is sometimes clinically unsatisfactory; it may even occasionally deteriorate to the extent that repeat scanning or scanning without fat suppression is required. Magnetic field (B 0 ) and radiofrequency (RF) field inhomogeneities are among the known causes of this problem, and they may be both scanner-and patient-dependent. For imaging of the spine, the problem is often exacerbated because of a patient's anatomic geometry and the use of a phasedarray coil, which is necessary for sufficient signal-tonoise ratio (SNR) and spatial coverage.The three-point Dixon (TPD) technique (4 -9), in which the chemical shift difference between water and fat is encoded into three images with different echo shifts, can provide separate water-and fat-only images, and therefore may serve as an alternative to the CHESS technique for fat suppression. In the TPD technique, field inhomogeneity manifests as image-phase offsets and can be removed by a postprocessing phase correction. As a result, high-quality water-and fat-only images can be generated even in the presence of substantial B 0 and RF field inhomogeneities. However, two prominent drawbacks to the TPD technique have hindered its widespread use. The first is the long scanning time required by the multipoint data acquisition. Contributing to this problem-and less well-known-is the additional increase in scanning time or reduction in slice coverage that res...

Purpose To assess the impact of accelerated acquisitions on the spectral quality of volumetric MR spectroscopic imaging (MRSI) and to evaluate their ability in detecting metabolic changes with mild injury. Materials and Methods The implementation of a generalized autocalibrating partially parallel acquisition (GRAPPA) method for a high-resolution whole-brain echo planar SI (EPSI) sequence is first described and the spectral accuracy of the GRAPPA-EPSI method is investigated using lobar and voxel-based analyses for normal subjects and patients with mild traumatic brain injuries (mTBI). The performance of GRAPPA was compared with that of fully-encoded EPSI for 5 datasets collected from normal subjects at the same scanning session, as well as on 45 scans (20 normal subjects and 25 mTBI patients) for which the reduced k-space sampling was simulated. For comparison, a central k-space lower-resolution 3D-EPSI acquisition was also simulated. Differences in individual metabolites and metabolite ratio distributions of the mTBI group relative to those of age-matched control subjects were statistically evaluated using analyses divided into hemispheric brain lobes and tissue types. Results GRAPPA-EPSI with 16-min scan time yielded robust and similar results in terms of MRSI quantitation, spectral fitting, and accuracy with that of fully sampled 3D-EPSI acquisitions and was more accurate than central k-space acquisition. Primary findings included high correlations (accuracy of 92.6%) between the GRAPPA and fully sampled results. Conclusion Although the reduced encoding method is associated with lower SNR that impact the quality of spectral analysis the use of parallel imaging method can lead to same diagnostic outcomes as of the fully sampled data when using the sensitivity-limited volumetric MRSI.