Background. Squamous cell carcinoma of the oral cavity is generally caused by the long-term impact of known risk factors, e.g. tobacco and alcohol, along with chronic traumatisation. A number of studies now implicate HPV infection in head and neck tumour carcinogenesis but the exact role of HPV infection in the oral cavity remains unclear. Methods. In this study, we evaluated 78 patients with oral squamous cell carcinoma (OSCC) for the expression of protein p16 in the context of HPV positivity and its influence on the overall survival rate, disease location, staging and grading. Results. Regarding the tumour location, no significant difference was found between HPV-positive and HPV-negative patients, nor between p16-positive and p16-negative patients. There was also no trend in terms of HPV status and stage, and differentiation of carcinoma. There was no effect on HPV-positive patients relative to the time to progression (P=0.84) and overall survival rate (P=0.78). P16 positivity was not found to have an effect on the overall survival rate of patients (P=0.41) and there was no correlation between p16 positivity relative to the time to progression (P=0.66). Conclusions. In summary, the data suggest that there is no effect of HPV status on the prognosis of OSCC patients compared to other HNSCC locations.

Objectives. Medication-related osteonecrosis of the jaw (MRONJ) is defined as exposed bone in the maxillofacial region persisting for more than eight weeks in patients who are or were treated with antire sorptive or antiangiogenic agents and had no radiation therapy to the craniofacial region or obvious metastatic disease of the jaws. It is a recognised side effect of antiresorptive or antiangiogenic medication. To date, there is no specific gold standard treatment for MRONJ cases. The aim of this study was to evaluate the successful rate of surgical treatment with adjuvant local application of platelet rich fibrin. Methods. 40 patients treated with necrotic bone resection and adjuvant local application of platelet-rich fibrin (PRF) were included. Treatment outcomes were evaluated after 12 months. Results. The outcome of surgical treatment was successful in 34 of all 40 patients (85%), in 12 months follow-up. If we evaluate only cases where removal of all necrotic bone was possible the success rate was increased to 94%. A significant association between size of necrotic bone and treatment response was found (P=0.014, Wilcoxon rank sum test with continuity correction). Conclusions. Surgical treatment of MRONJ with adjuvant local PRF application proved to be very effective and safe, especially in early stages when all necrotic bone can be easily removed.

Atherosclerosis as a main etiopathogenetic source for coronary artery disease (CAD) development is intimately related to dynamic changes in the extracellular matrix (ECM). Elevated levels of MMP-13 have been observed in human atherosclerotic plaques which could also involve variability in MMP-13 gene. The aim of the study was to associate rs640198 polymorphism with CAD and/or with its severity.The study comprised 1071 consecutive patients with suspected or known coronary artery disease (CAD), confirmed by coronary angiography.Genotyping for the rs640198 polymorphism in MMP-13 gene was performed using Taqman® assay. The TT and TG genotypes of rs640198 polymorphism in MMP-13 gene confer the significantly increased risk of triple vessel disease compared to patients without atherosclerotic lesions in coronary arteries (odds ratio = 1.64, Pcorr = 0.05). Furthermore, an increased risk of having 5 and more stenoses (odds ratio = 1.90, Pcorr = 0.004) was observed in TT and TG carriers (sensitivity of 0.613 and a specificity of 0.544; power of the test is 0.87).The T allele of MMP-13 intron polymorphism rs640198 is associated with the severity of coronary artery disease, represented by the number of affected arteries as well as by the number of stenoses confirmed by coronarography.

Úvod: Maligní tumory orofaciální oblasti představují asi 2-3 % všech zhoubných onemocnění, a patří tak mezi 10 nejčastějších malignit. Přibližně 85-95 % maligních tumorů hlavy a krku připadá na spinocelulární karcinom, který tak díky svému častému výskytu představuje malignitu všeobecně známou.Předmět sdělení: V tomto článku jsme se zaměřili na dva případy zcela vzácných tumorů orofaciální oblasti, se kterými jsme se setkali na Klinice ústní, čelistní a obličejové chirurgie LF MU a FN Brno. Jde o chondroblastický osteosarkom s incidencí 0,07 : 100 000 a glomangiopericytom tvořící asi 3 % všech nádorů hlavy a krku. V prvním případě jde o vysoce maligní novotvar, v druhém případě o nízce nebo hraničně maligní tumor.Klíčová slova: glomangiopericytom -hemangiopericytom -maxila -čelistní dutina -horní čelist -chondroblastický osteosarkom SUMMARY Introduction: Malignant tumours located in maxillofacial region represent approximately 2-3% of all cancers and thus belonging to 10 most frequent malignancies. Approximately 85 to 95% of oral cancer is squamous cell carcinoma, which is well known type of cancer.Background: In these articles we report two uncommon tumors of maxillofacial region, which we encountered on department of Oral and Maxillofacial Surgery University Hospital Brno. The first rare tumour is chondroblastic osteosarcoma with incidence 0,07 cases per 100 000 population per year, the second is glomangiopericytoma, which represents 3% of all tumors of head and neck. Chondroblastic osteosarcoma is highly malignant tumor, while glomangiopericytoma belongs to category of borderline and low-malignant-potential soft-tissue tumors.

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