Optical coherence tomography (OCT) is a promising research tool for brain imaging and developmental biology. Serving as a three-dimensional optical biopsy technique, OCT provides volumetric reconstruction of brain tissues and embryonic structures with micrometer resolution and video rate imaging speed. Functional OCT enables label-free monitoring of hemodynamic and metabolic changes in the brain in vitro and in vivo in animal models. Due to its non-invasiveness nature, OCT enables longitudinal imaging of developing specimens in vivo without potential damage from surgical operation, tissue fixation and processing, and staining with exogenous contrast agents. In this paper, various OCT applications in brain imaging and developmental biology are reviewed, with a particular focus on imaging heart development. In addition, we report findings on the effects of a circadian gene (Clock) and high-fat-diet on heart development in Drosophila melanogaster. These findings contribute to our understanding of the fundamental mechanisms connecting circadian genes and obesity to heart development and cardiac diseases.

The services provided in public health center should be based on the felt need of the population to increase attendance as well as utilization of dental services, thereby increasing the oral health status of the population.

Background: Diabetes mellitus (DM) is associated with high morbidity and mortality. It has various complications. Risk factor control is effective way of prevention. Current study was conducted to know demographic profile including risk factors related to diabetes mellitus in patients attending a tertiary health care institute of Rajasthan.Methods: This cross-sectional study was conducted for the duration of six months. In the study 623 diabetes mellitus type 2 patients were included and subjected to evaluation of various demographic parameters and risk factors like age, sex, economic status, area of residence, obesity, hypertension (HTN), lack of exercise, smoking, dyslipidemia and positive family history.Results: Mean age of diabetic population was 62 years. Male-female, urban-rural ratios were nearly 1:1 and 3:2 respectively. Nearly 7 % patients were found to be below poverty line (BPL). On risk factor evaluation of 623 diabetic patients it was found that 598 (96%) patients had lack of exercise, 406 (65.2%) patients had age more than 60 years, 394 (63.2%) patients had dyslipidemia, 210 (33.7%) patients were smoker as per the mentioned criteria, 144 (23.1%) patients were obese, 118 (19%) patients had HTN before emergence of DM and 90 (14.4%) patients had positive family history.Conclusions: High prevalence of risk factors in Indian community is alarming. Health education, promotion of exercise, favourable life style, dietary modification, cessation of smoking, screening programmes for early detection of derange blood pressure, blood sugar, lipid profile can be effective prevention strategies.

A device based on Polarization sensitive optical coherence tomography is developed to monitor blood glucose levels in human subjects. The device was initially tested with tissue phantom. The measurements with human subjects for various glucose concentration levels are found to be linearly dependent on the degree of circular polarization obtainable from the PS-OCT.

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