A novel, green and efficient visible-light-promoted decarboxylative aminoalkylation reaction of imidazo[1,2-a]pyridines with N-aryl glycines has been described.

No abstract

A new and efficient visible-light-promoted dehydrogenative cross-coupling reaction of imidazo­[1,2-a]­pyridines with α-amino carbonyl compounds toward imidoyl imidazo­[1,2-a]­pyridines is developed. A diverse range of imidazo­[1,2-a]­pyridines undergoes the dehydrogenative imidoylation smoothly with α-amino carbonyl compounds to access the corresponding products in satisfactory yields. We have also proposed the possible reaction mechanism based on preliminary mechanistic studies. The synthetic method has the advantages of wide substrate scope, good functional tolerance, and mild reaction conditions, which make this transformation more practical and sustainable.

A novel and highly efficient dehydrogenative cross-coupling­ reaction between α-amino carbonyl compounds and azoles by copper catalysis using di-tert-butyl peroxide (DTBP) as an oxidant is described­. A diverse range of azoles undergo the dehydrogenative imidoylation smoothly with various α-amino carbonyl compounds for the exclusive formation of the corresponding N-imidoyl azoles in high yields under air. The synthetic method has the advantages of good functional-group tolerance, wide substrate scope, excellent yields, and simple operation­, thus providing a convenient and practical protocol for the synthesis of functionalized azoles.