The nearshore fish community of the Port River-Barker Inlet Estuary was sampled between January 1986 and May 1987 using a beach seine to determine the effect of thermal effluent on the community structure and nursery function of the estuary. A total of 41 species was found in the estuary, with decreasing numbers of species with decreasing distance from the thermal outfall. Cluster analyses and multi-dimensional scaling ordination separated the thermally polluted sites from the non-affected sites. During the summer/auturnn period, thermal effluent only affected water temperature and the species compositions in the inner estuary, and the estuary-opportunistic species Aldrichetta forsteri, Arripis georgiana, A. truttacea and Hyporhamphus melanochir avoided the area at this time. During winterlspring months, thermal effluent acted in the opposite way, with A. forsteri attracted to the warmer waters of the inner estuary. The extended growth season for this species and significantly higher growth rates promoting premature movement out of the inner estuary for S. punctata were additional direct effects. These latter effects may alter the population structures of these species by increasing their vulnerability to heavy localized fishing intensity, aggregation of natural predators and point-source pollution. The species composition of the fish fauna of the estuary may also be indirectly affected by the thermal pollution-mediated seagrass loss in the inner estuary and a method is described to test this hypothesis.

The fecundity, size at sexual maturity, sex ratios and total mortality of Haliotis mariae on the Dhofar coast of the northern Arabian Sea were measured. These data, and estimates of the growth rate, were used for yield-per-recruit and egg-per-recruit analyses. Maximum yields occur at 3+ to 4+ years of age, depending on the natural mortality rate chosen. At the present age at first capture egg production levels are 2-29% of the unfished stock, depending on estimates of the fishing mortality rate and the natural mortality rate, and are considered to be far too low to maintain recruitment. At 40% egg production, of the maximum possible the age at first capture is 4 to 4.5 years, i.e. 105-115 mm shell length, depending on site.

Background: Randomized trials, although not all, suggest exercise therapy improves treatment completion rates / relative dose intensity in patients with early-stage breast cancer receiving adjuvant chemotherapy (CT). In addition, preclinical studies show that exercise therapy adds to the antitumor activity of standard CT in murine models of breast cancer. We evaluated the association between exercise and pathologic complete response (pCR) rate (i.e., ypT0ypN0) in patients receiving neoadjuvant CT for operable breast cancer. Methods: Using a prospective design, patients with stage I-III breast cancer receiving anthracycline-taxane (± trastuzumab) neoadjuvant CT participating in a multicenter, national cohort study in France (CANTO, NCT01993498) completed questionnaire assessing self-reported exercise behavior (GPAQ 16). Multivariate logistic models were performed to determine the relationship between pre-CT exercise exposure (total MET-h/wk categorized into the proportion of patients meeting WHO exercise guidelines, the equivalent of ≥10 MET-h/wk), pCR rates, CT± trastuzumab dose reductions, delays, treatment completion or interruptions for the overall cohort and on the basis of clinical subtype. Results: Between March, 2012 to December, 2014, a total of 989 patients participating in CANTO received neoadjuvant CT and completed GPAQ 16. Here we present interim analyses on 608 patients. Fifty-four percent of patients engaged on of ≥10 MET-h/wk prior to CT administration. In multivariable analysis for the overall cohort, exercise exposure was not associated with higher pCR (p=0.69). The pCR rate was 27.7% for patients reporting <10 MET h/wkcompared with 28.0% for those reporting ≥ 10 MET-h/wk (OR, 1.02; 95% CI, 0.71-1.45). Stratification analyses indicated no differences on the basis of clinical subtype for hormone receptor (HR) positive/HER2 negative (<10 MET h/wk: 15.1% vs. ≥ 10 MET h/wk: 16.5%; OR, 0.95, 0.41-2.16); HER2 positive (<10 MET h/wk: 38.1% vs. ≥ 10 MET h/wk: 32.5%; OR, 0.62, 0.28-1.35); or triple-negative disease (<10 MET h/wk: 33.3% vs. ≥ 10 MET h/wk: 36.7%; OR, 1.04, 0.52-2.10). Rates of CT dose reductions (<10 MET h/wk: 16.1% vs. ≥ 10 MET h/wk: 18.3%), CT dose delays (<10 MET h/wk: 19.9% vs. ≥ 10 MET h/wk: 19.8%), CT completion (<10 MET h/wk: 12.03% vs. ≥ 10 MET h/wk: 11.45%) trastuzumab interruptions (<10 MET h/wk: 9.01% vs. ≥ 10 MET h/wk: 7.95%) were also not different on the basis of exercise exposure. Conclusion: On the basis of interim analyses, higher pretreatment exercise exposure is not associated with higher clinical response or treatment tolerability in breast cancer patients receiving uniform conventional neoadjuvant CT. Full results will be presented at the meeting. Citation Format: Baker JL, Di Meglio A, El Mouhebb M, Iyengar NM, Michiels S, Cottu P, Lerebours F, Coutant C, Lesur A, Tredan O, Soulie P, Vanlemmens L, Jouannaud C, Levy C, Everhard S, Martin A-L, Arveux P, Fabrice A, Vaz Luis I, Jones LW. Association between exercise, pathological complete response, and treatment tolerability in patients receiving neoadjuvant chemotherapy for operable breast cancer: Results from the CANTO study [abstract]. In: Proceedings of the 2018 San Antonio Breast Cancer Symposium; 2018 Dec 4-8; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2019;79(4 Suppl):Abstract nr P1-15-03.