Pulmonary sequestration is a congenital bronchopulmonary foregut malformation in which a segment of lung parenchyma is not connected to the tracheobronchial tree. This abnormal segment receives a blood supply from the systemic circulation. Multiple imaging modalities have been used to demonstrate the vascular anatomy of the sequestration. Different magnetic resonance angiography (MRA) techniques have been employed in the identification of these anomalous vessels. We report a case of pulmonary sequestration diagnosed by MRI with the use of contrast enhanced three-dimensional MRA.

Purpose: Taxane chemotherapy is commonly used in the management of breast cancer. Hair loss (alopecia) is an expected side effect which may have a significant effect on quality of life. Alopecia is normally temporary but permanent chemotherapy-induced alopecia (pCIA) is increasingly recognised especially following docetaxel chemotherapy. However, the prevalence following docetaxel is not well understood and there is no published literature for paclitaxel chemotherapy. The aim of this study is to investigate the prevalence and patterns of pCIA resulting from both docetaxel and paclitaxel chemotherapy at two tertiary UK cancer centres. Methods: In collaboration between Clatterbridge Cancer Centre and The Christie NHS Foundation Trusts, a retrospective survey was conducted for breast cancer patients who had received taxane chemotherapy in the neoadjuvant and adjuvant settings. Patients who had concluded chemotherapy at least a year previously were contacted by post and invited to participate by completing a questionnaire and returning it to their treatment centre. Data collected included the incidence and pattern of pCIA using the Savin pictorial hair loss scale, and the methods used by patients to manage it. Fisher's exact test was used to compare pCIA between the docetaxel and paclitaxel cohorts.Results: 383 patients responded to the survey (a 63.3% overall response rate). These comprised 245 patients receiving docetaxel and 138 patients treated with paclitaxel.pCIA was reported by 23.3% of patients receiving docetaxel and 10.1% paclitaxel (p < 0.01). Overall 16.7% of patients in both groups reported the ongoing use of products or appliances such as wigs to camouflage their pCIA. In the docetaxel group, pCIA appeared to be more frequent in post-menopausal women than peri-or premenopausal women (37.8%, 12.3% and 19.6% respectively [Chi-square test p < 0.01]).Also in the docetaxel group, there appeared to be a trend for more severe scalp alopecia when the patient also received an aromatase inhibitor (AI) or tamoxifen and this difference was most marked in those who had received both an AI and tamoxifen as components of their treatment regime (p = 0.04). The use of scalp cooling was How to cite this article: Chan J, Adderley H, Alameddine M, et al. Permanent hair loss associated with taxane chemotherapy use in breast cancer: A retrospective survey at two tertiary UK cancer centres. Eur J Cancer Care.

Background: Adjuvant docetaxel with cyclophosphamide (TC) chemotherapy use in the community is common based on its improved disease outcomes compared to doxorubicin with cyclophosphamide (AC) treatment, lack of cardiac toxicity associated with anthracyclines, and perceived low incidence of febrile neutropenia (FN). In the pivotal trial of AC versus TC, the incidence of FN in breast cancer patients who received TC treatment was 4% in patients under 65 years and 8% in patients greater than 65 years. Growth factors (CSF) were not used in the trial, but antibiotics were used significantly. FN rates of 11.6% to 50% have been reported in multiple small studies, prompting warnings that primary prophylaxis with growth factor should be used. The true incidence of FN in community based patients may be higher than in the original clinical trial population as non-trial patients may have risk factors known to increase the risk for chemotherapy-induced FN, including increased age or other comorbid conditions. We wanted to know the incidence of FN in patients receiving TC chemotherapy who were not given primary prophylaxis with CSF. Methods: Using our electronic medical record system, a retrospective review of patients starting TC for breast cancer in 2010 at Kaiser Permanente Northern California was included. Patients had started a four or six cycle regimen of docetaxel 75 mg/m2 and cyclophosphamide 600 mg/m2 every 21 days. Patients were stratified into two groups: (1) CSF primary prophylaxis given with the first cycle versus (2) no CSF primary prophylaxis given with the first cycle. CSF prophylaxis was given by physician choice. FN episodes were defined with a clinical diagnosis code for FN from emergency department visits or hospitalizations. The primary outcome was the incidence of TC-induced FN in patients who did not receive CSF primary prophylaxis with the first cycle of treatment. Results: 332 patients with a mean age of 57.9 years (range 30.5 to 83.6 years) were included. Of these, 204 (61.4%) did not receive primary CSF prophylaxis (mean age 57.4 years, range 30.5 to 83.6 years), and 128 (38.6%) received primary CSF prophylaxis (mean age 58.5 years, range 36.6 to 82.4 years). The incidence of FN during any cycle was 24.5% (50/204) in those who did not receive primary CSF prophylaxis and 8.6% (11/128) in those who did (p=0.0003). Patients were hospitalized for FN for a total of 174 days (mean 3.2 days, range 1 to 13 days). Mean days hospitalized were 3.2 in each group. We will present risk factors associated with the development of FN. Conclusion: In the largest population based report to date, we report the incidence of febrile neutropenia to be 24.5% in patients not receiving primary CSF prophylaxis. The rate is higher than originally reported for TC. Primary prophylaxis with CSF should be considered when treating this patient population with TC chemotherapy. Further analysis, including risk factor assessment, will be presented. Citation Information: Cancer Res 2011;71(24 Suppl):Abstract nr P5-18-05.

PURPOSE Bladder-sparing trimodal therapy (TMT) is an alternative to radical cystectomy (RC) according to international guidelines. However, there are limited data to guide management of nonmetastatic clinically node-positive bladder cancer (cN+ M0 BCa). We performed a multicenter retrospective analysis of survival outcomes in node-positive patients to inform practice. METHODS Data from patients diagnosed with cN+ M0 BCa were collected from participating UK Oncology centers offering both TMT and RC. Overall survival (OS) and progression-free survival (PFS) outcomes were collected with details of treatment and clinical factors. RESULTS A total of 287 patients with cN+ M0 BCa were included in the survival analysis. Median OS across all patients was 1.55 years (95% CI, 1.35 to 1.82 years). Receiving radical treatments was associated with improved OS (hazard ratio [HR], 0.32; 95% CI, 0.23 to 0.44; P < .001) compared with receiving palliative treatment. Radically treated patients (n = 163) received RC (n = 76) or radical dose radiotherapy (RT, n = 87); choice of radical treatment showed no association with OS (HR, 0.94; 95% CI, 0.63 to 1.41; P = .76) or PFS (HR, 0.74; 95% CI, 0.50 to 1.08; P = .12) on multivariable analysis. CONCLUSION Patient cohorts with cN+ M0 BCa had equivalent survival outcomes whether treated with surgery or radical RT. Given the known morbidities of RC—in a patient group with poor survival—this study confirms that bladder-sparing TMT treatment should be a treatment option available to all patients with cN+ M0 BCa.

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