Comparisons were made between the immune responses evoked during the course of chronic and patient infections of Litomosoides sigmodontis in susceptible BALB/c mice and non-patent infections in resistant B10.D2 mice. Early antigen specific responses of spleen cells were weak in both mouse strains. However, by day 58 post infection a strong Th2 response, as determined by production of IL-4, IL-5 and IL-10, was observed in BALB/c mice but not in B10.D2 mice. Antibody responses seemed to appear sooner in B10.D2 than in BALB/c mice, and these differentially recognised two antigens of 15 kD and 80 kD.

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In experiment B, where the pumps were removed, the leu cocyte counts increased again.These animals, treated with interferon-y prior to infection, showed higher immunoglobulin titers (IgG and IgM) in the early phase of infection. After one week of treatment, at the day of infection, the neutrophil counts were significantly increased, whereas the eosinophils were reduced during the first 14 days. Up to week 20 p.i. microfilaridermia rea ched titers which were twice as high as in the control group, but this difference was not significant. Fotir of the treated and two of the control animals were dissected 35 weeks post infection in order to carry out lymphocyte transformation tests. No differences were seen between the treated and the untreated control group. Macrophages (McJ>) isolated from the peritoneum of patent animals showed a high baseline proliferation, whereas coincubation of M

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understand the genetic mechanisms of susceptibility to ivermectin and acquired refractiveness.2. M. martini is normally susceptible to suramin, levamisole and albendazole.