Instant radiopharmaceuticals—just add [99mTcO4]− in water! Half‐sandwich complexes of the type [(RCOCp)99mTc(CO)3] (e.g. 1) were synthesized in a single step in water from [99mTcO4]−. The acidification of the Cp ring by a carbonyl substituent and the use of K2[H3BCO2] as a reducing agent and in situ source of CO are instrumental in the synthesis.

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The radionuclide 99m Tc is among the most widely used isotopes in diagnostic nuclear medicine. [1] It is cheap, exhibits good decay characteristics, and typically burdens the patient with a low radiation dose. Whereas in the past 99m Tccomplexes were preferentially applied as perfusion agents, [2] a challenge now lies in combining a 99m Tc complex with a targeting molecule such as a tumor-specific peptide or a small Scheme 2. a) 1) Tf 2 O, pyridine, 99 %, 2) Pd(OAc) 2 , PPh 3 , Et 3 N, HCO 2 H, 97 %; b) ethylene glycol, PPTS, 92 %; c) 1) LiAlH 4 , 2) HCl, 83 % (2 steps); d) 1) L-Selectride, 2) LiAlH 4 , 61 % (2 steps). PPTS pyridinium p-toluenesulfonate.

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