52 RBTI -Revista Brasileira Terapia Intensiva Artigo originAl RESUMO JUSTIFICATIVA E OBJETIVOS: Determinar as características clínicas, epidemiológicas e laboratoriais, bem como a mortalidade dos pacientes adultos com sepse, admitidos na Uti geral de hospital privado terciário do estado de Pernambuco. MÉTODO: Estudo tipo coorte prospectiva e observacional, que incluiu pacientes adultos admitidos com o diagnóstico de sepse ou que a desenvolveram durante a internação na Uti do Hospital Português de recife durante o período de seis meses. Foram colhidos dados clínicos e laboratoriais, bem como, calculados os escores APACHE ii e SoFA, sendo os pacientes re-avaliados ao final da internação para definir o desfecho clínico, ou seja, para alta, óbito, ou transferência da Uti. RESULTADOS: Foram incluídos 199 pacientes, dos quais 112 (56,3%) tiveram alta da Uti. Cerca de 67,8% da população foi composta por idosos (maiores de 65

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Introduction: Acquired hemophilia A is very rare autoimmune disorder caused by an autoantibody to factor VIII that interferes with its coagulant function. It may be associated with a number of conditions such as lymphoproliferative disorders, drugs and solid malignancies. Hemarthrosis in Acquired hemophilia A is very rare clinical presentation and was never reported in cases induced by penicillin. Case presentation: We report a 65-year-old male, born and living in Brazil, who presented hemorrhagic episodes complicated with joint hemarthrosis due to acquired hemophilia A caused by a commonly used drug, Benzathine penicillin.Disease management was focused on controlling bleeding, primarily with the use of factor VIII inhibition bypassing activity and eradicate the autoantibody using various immunosuppressants. The challenges in manage this case included delayed diagnosis, durable remissions, difficulty achieving hemostasis. Clinical and laboratory coagulation response has improved eight weeks after only with the administration of double immunosuppression medication: corticosteroid and cyclophosphamide. Conclusion: This case gives us the lesson that prompt diagnosis and treatment achieved by hematologists may improve the prognosis and prevent severe bleeding. Early detection is vital to improving outcomes.