7Uniqueness of properties and robustness of structure makes porphyrins nature's favorite catalysts. 8 They have grabbed human attention since decades due to its intense colours and in modern times the 9 interest in these molecules has sharply increased, owing to their use for handling some tough 10 problems, including medical and environmental issues. Nowadays much attention is being focused 11 on the development of materials for the capture and conversion of CO 2 into value added products and 12 porphyrins are not lagging behind in extending their favor. The idea that porphyrins are poor 13 absorption materials since are generally plnar compounds has been belied by the development of new 14 efficient porphyrin-based materials, and the development of reliable synthetic routes for porphyrin 15 based nanoreactors such as covalent-organic frameworks (COF) and metal-organic frameworks 16 (MOF) as porous materials has facilitated to overcome the underlying CO 2 reactivity challenges.17Porphyrin-based materials behaving as nanoreactors are very promising for CO 2 capture and 18 conversion due to the presence of basic pyrrole containing macrocyclic cavity and large aromatic 19 rings which facilitates strong interactions with CO 2 . This review is intended to provide an overview 20 of up-to-date progress made in the area of the CO 2 capture and conversion involving porphyrin-based 21 molecular materials and nanoreactors, bearing important structural features in terms of surface area, 22 porosity, CO 2 uptake and the possibility of its catalytic conversion to chemically valuable products.

Photodynamic therapy (PDT) is a selective and minimally invasive therapeutic approach, involving the combination of a light-sensitive compound, called a photosensitizer (PS), visible light and molecular oxygen. The interaction of these per se harmless agents results in the production of reactive species. This triggers a series of cellular events that culminate in the selective destruction of cancer cells, inside which the photosensitizer preferentially accumulates. The search for ideal PDT photosensitizers has been a very active field of research, with a special focus on porphyrins and porphyrin-related macrocycle molecules. The present study describes the photophysical characterization and in vitro phototoxicity evaluation of 5,10,15,20-tetra(quinolin-2-yl)porphyrin (2-TQP) as a potential PDT photosensitizer. Molar absorption coefficients were determined from the corresponding absorption spectrum, the fluorescence quantum yield was calculated using 5,10,15,20-tetraphenylporphyrin (TPP) as a standard and the quantum yield of singlet oxygen generation was determined by direct phosphorescence measurements. Toxicity evaluations (in the presence and absence of irradiation) were performed against HT29 colorectal adenocarcinoma cancer cells. The results from this preliminary study show that the hydrophobic 2-TQP fulfills several critical requirements for a good PDT photosensitizer, namely a high quantum yield of singlet oxygen generation (Φ∆ 0.62), absence of dark toxicity and significant in vitro phototoxicity for concentrations in the micromolar range.

No abstract

No abstract

No abstract