Meropenem is a broad-spectrum carbapenem widely used to treat both Gram-positive and negative bacterial infections, including extended-spectrum beta-lactamase-producing microbes. We describe the occurrence of thrombocytopenia and hypersensitivity in a boy receiving intravenous meropenem for intra-abdominal sepsis secondary to perforated appendicitis. The patient developed a pruritic maculopapular rash with occasional petechiae, associated with severe thrombocytopenia, after 7 days of meropenem administration. Investigations for other causes of thrombocytopenia, including possible line sepsis, were unfruitful, and the thrombocytopenia did not resolve until cessation of meropenem. Drug-induced reactions should be considered in children receiving meropenem who present with a rash and thrombocytopenia.

pregnancy, birth, growth, development, physical examination and vaccination, to promote and maintain health. We identified, among other codes, the Logical Observation Identifiers Names and Codes, a universal standard and electronic database for clinical care and management, applicable to child health care (such as codes 8339-4Birth weight Measured and 8287-5Head Occipital-frontal circumference by Tape measure) for registering the first feature of a (rare) disabling condition. Medical guidelines on Shwachman Diamond Syndrome (SDS) and Thalassemia Major were reviewed on recommended measurements. LOINC codes specific for SDS and thalassemia were applied in text mining for processing PubMed document sets. Results We identified a subset of international interoperable codes to help to identify (rare) disabling conditions presenting in the first years of life. Child health handbooks can be enriched with a simple laboratory test to help diagnose diseases as a possible part of a (rare) condition.Text mining is a powerful tool for processing PubMed document sets to identify diagnostic test in literature. Using unsupervised techniques such as clustering and spatial placement, with one can quickly gain insight into the contents of the documents, discover hidden properties and determine how to further explore and label the data. 2 Terms that belong to LOINC codes in filtering the whole (ranked) document set one can identify also the important rare disease papers that most likely are relevant for a medical test. Conclusions The application of specific code-sets ensures the harmonization of data and the possibility of data exchange. As demonstrated with the LOINC the establishment of an interoperable child health record, including children with chronic illness and disabilities, is feasible. Collaboration between paediatricians, families, health system managers and data services is necessary to provide digital solutions to support the SDG3.

positive results from 1249 CSF samples tested using FA-M/E technology. Of the positive analyses, 50 (19.5%) were bacterial and 206 (80.5%) were viral/fungal pathogens. 41/50 (82%) bacterial isolates were TP and 6/50 (12%) False Positives (FP) and 3 unconfirmed by reference tests. The bacterial analytes detected include S.Pneumonia 19 (15 TP, 2 FP, 2 unconfirmed) S.Agalactiae 13 (11 TP, 2 FP), E.Coli K1 13 (11TP, 1 FP, 1 unconfirmed), HiB 3 (2 TP, 1 FP), N. Meningitidis 1 (1 TP), L. Monocytogenes 1 (1 TP). 41/50 (82%) bacterial isolates were TP's confirmed by reference testing, 6/50 (12%) were FP and 3/50 (6%) were unconfirmed by reference testing. Conclusions The FA-M/E panel can detect 6 common bacterial organisms in the CSF with a TP rate of 82% and a FP rate of 12%. The PCR panels ability to rapidly identify CNS pathogens within 60 minutes makes it a useful diagnostic tool in emergency settings. However five out of eight studies included were retrospective and as a result clinical data may had been lost, some samples were retrospectively tested after 2 years, thus we cannot determine the exact impact the FA-M/E would have on clinical outcomes. Due to study design or insufficient CSF volume, many samples did not undergo adjudicatory testing to validate FA-M/E panel results.The FA-M/E panel and rapid PCR panels are feasible adjuncts to conventional testing but larger studies in different settings are required before they can replace current practice.

compared to those referred prior to implementing the measures. Additionally, I interviewed staff and patients to obtain their views on the changes introduced. Results The characteristics of the young people from both the pre and post intervention group were comparable. Of note, prior to intervention, KPI was met in 36.7% of young people with the remaining 63.3% breaching KPI. The interventions have so far resulted in an overall improvement with more young people meeting KPI and less deterioration seen prior to assessment with interventions being viewed as positive in general by both staff and young people.Abstract 1062 Figure 1 Referrals trends over 5 years Conclusion It is important that young people receive the best standard of care catered to their specific needs. These results are promising and provide a further framework for managing this group of patients as although the adverse effects of the covid-19 pandemic have lessened, the long-term effects on mental health are not fully appreciated.