Background/Aim: PTP1B tyrosine phosphatase is involved in the development of many types of cancers, such as breast cancer or lung cancer. Therefore, PTP1B is a promising target for anticancer therapy. The purpose of this review was to present the studies on selected PTP1B inhibitors as a possible treatment and describe the latest trends of current research in this field. Materials and Methods: This literature review was performed using the PubMed database and the analysis of previous research studies of our Department. Results: Recent studies have shown that PTP1B, due to its implication in oncogenic transformation, represents a promising drug target. Conclusion: The selected compounds that are effective PTP1B inhibitors can be considered a promising anticancer treatment, both as monotherapy and in combination with other anticancer drugs. PTP1B Activates Oncogenic Src KinasesPTP1B contributes to oncogenic properties through activation of non-receptor tyrosine kinase Src, which is deregulated in multiple tumor types (11). The crucial role of Src kinases in tumor development is due to their effect on proliferation, survival, adhesion, migration, invasion and metastasis. Src kinase activity has been reported to be elevated in many human cancer cell lines, e.g. breast cancer, lung cancer and 3379

Background: Tattoo is becoming a more and more common form of body decoration of people from representatives of various professions.The aim of this study was: what is the opinion of university students about medical staff having visible tattoos. Material and methods: The study was conducted among the students of four universities in Gdańsk. The questionnaire contained questions about the acceptance of visible tattoos in people working in medical professions. The respondents were also asked about their attitudes to tattoos as a form of body decoration and whether they had tattoos themselves. The statistical analysis was performed using IBM SPSS Statistics 25 software. Results: Filled-in questionnaires were obtained from 676 respondents, including 477 students of the medical university and 199 students of non-medical universities. The students who have tattoos themselves accept visible tattoos in healthcare professionals to a significantly greater extent (92%) than those who do not have tattoos, but the acceptance of visible tattoos in healthcare professionals in this group turned out to be very high too (75%). The respondents most readily accepted a visible tattoo on the skin of a laboratory diagnostician (75%). Conclusions: University students, regardless of their university profile, consider a visible tattoo as a completely acceptable phenomenon in healthcare professionals.