We report a novel, facile, and asymmetric approach for the synthesis of the anti-tumor alkaloid (+)-crispine A via a highly diastereoselective N-acyliminium cyclization reaction as a key synthetic step.

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A New Asymmetric Synthesis of the Antitumor Alkaloid (R)-(+)-Crispine A. -A facile synthesis of title compound (I) is based on a diastereoselective N-acyliminium cyclization reaction as the key step. -(ALLIN*, S. M.; GASKELL, S. N.; TOWLER, J. M. R.; PAGE, P. C. B.; SAHA, B.; MCKENZIE, M. J.; MARTIN, W. P.; J. Org. Chem. 72 (2007) 23, 8972-8975; Dep. Chem., Loughborough Univ., Loughborough, Leicestershire LE11 3TU, UK; Eng.) -Nuesgen 10-225

N-Acyliminium Cyclization as an Approach for an Asymmetric Synthesis of the Pyrrolo[2,1-a]benzazepine Ring System. -The key step is a stereoselective N-acyliminium cyclization. -(ALLIN*, S. M.; TOWLER, J. M. R.; ELSEGOOD, M. R. J.; SAHA, B.; PAGE, P. C. B.; Synth. Commun. 42 (2012) 6, 872-882, http://dx.