Introduction: Spinal and bulbar muscular atrophy is a progressive neuromuscular disease that leads to muscle weakness and reduced physical function. Benefits of physical therapy for people with spinal and bulbar muscular atrophy have not been report ed in the literature. Case report: A 62yearold male patient with spinal and bulbar muscular atrophy reported falling, dif ficulty walking and completing upright tasks, and showed clinical signs of low baseline function on examination. Transportation challenges made it difficult for this patient to attend frequent one-onone physical therapy sessions. Interventions and outcomes: A minimally super vised homebased exercise intervention was cho sen with the goal of safely improving his functional capacity. The 5visit clinical intervention, spread over 10 months, provided 3 exercise modules: sea tedtostanding postural alignment and core muscle activation; upright functional and endurance train ing; and balance training and rhythmic walking. Postintervention the patient had increased lower extremity muscle strength, improved balance, and reduced selfreported fatigue. Conclusion: Homebased exercises were well tol erated with no increase in creatine kinase. Multi ple clinical measures of strength and function im proved, possibly related to the patients' excellent motivation and compliance with the programme. Promising utilization of a minimally supervised homebased programme is described here.