Eikenella corrodens is a normal inhabitant of the human oral cavity and gastrointestinal and genitourinary tracts. Pleuropulmonary infections by this microorganism are uncommon. Pulmonary aspiration is a chief predisposing condition. Although the outcome is usually favorable, its distinctive antibiotic sensitivity pattern makes bacterial identification an important feature in dealing with this infection. The authors report a case of pleural empyema caused by co-infection with Eikenella corrodens and Porphyromonas asaccharolytica, in an immunocompetent diabetic patient with obstructive sleep apnea syndrome, followed by a discussion on the role of noninvasive ventilation in the development of this infection.

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