Introdução: O lúpus eritematoso sistêmico (LES) é uma doença autoimune, onde ocorre surgimento de autoanticorpos os quais levam a lesões de diversos órgãos e tecidos. As manifestações podem ser de intensidade variável, porém muitas vezes necessitam de internação hospitalar devido a quadros complicados que podem surgir com o decorrer da doença. Na última década houve um significativo aumento das taxas de diagnóstico de LES, porém há poucos dados disponíveis a respeito de número de internações mortalidade

Studies have suggested a potential role of endothelial dysfunction and atherosclerosis in the pathophysiology of COVID-19. Herein we tested whether brachial flow-mediated dilation (FMD) and carotid intima-media thickness (cIMT) measured upon hospital admission are associated with acute in-hospital outcomes in hospitalized COVID-19 patients. A total of 211 hospitalized patients with COVID-19 were submitted to assessments of FMD and mean and maximum cIMT (cIMTmean and cIMTmax) within the first 72 hours of hospital admission. Study primary outcome was a composite of intensive care unit admission, mechanical ventilation, or death during the hospitalization. These outcomes were also considered independently. Thrombotic events were included as a secondary outcome. Odds ratios (OR) and confidence intervals (CI) were calculated using unadjusted and adjusted multivariable logistic regression models. Eighty-eight (42%) participants demonstrated at least one of the composite outcomes. cIMTmean and cIMTmax were predictors of mortality and thrombotic events in the univariate analysis (cIMTmean and mortality: unadjusted OR 13.0[95%CI 1.7-105], P=0.015; cIMTmean and thrombotic events: unadjusted OR 13.0[95%CI 1.7-93]; P=0.013; cIMTmax and mortality: unadjusted OR 8.3[95%CI 1.3-53]; P=0.026; cIMTmax and thrombotic events: unadjusted OR 12.0[95%CI 2.0-74]; P=0.007). However, these associations were no longer present after adjustment for potential confounders (P=0.06-0.79). Additionally, FMD% was not associated with any outcome. In conclusion, cIMT and FMD are not independent predictors of clinical outcomes in hospitalized patients with COVID-19. These results suggest that subclinical atherosclerosis and endothelial dysfunction may not be the main drivers of COVID-19 complications in hospitalized COVID-19 patients.

Introduction The aim of the study was to identify factors associated with the causes of in-hospital morbidity and mortality in an elderly Brazilian population due to osteoporotic hip fractures. Method Retrospective cohort study involving a population over 60 years of age admitted to hospital due to osteoporotic hip fractures and followed up from hospitalization to outcome (discharge or mortality) from 2010 to 2018, in a public hospital in Brasília, the capital of Brazil. Multivariate analysis was performed using the Poisson regression model with a robust variance, observing the hierarchical model proposed and the receiver operating characteristic (ROC) curve to obtain the cutoff point for mortality incidence in relation the total length of hospital stay. Significance level was set as p < 0.05. The analyses were conducted using the SAS 9.4 software. Result The mean hospital mortality rate among the 402 patients involved was 18.4%, and the associations made with the outcome mortality were per relevance: respiratory infection, age over 90 years, high preoperative cardiovascular risk, chronic obstructive pulmonary disease (COPD) as comorbidity, serum hemoglobin level ≤ 10 and other infections. Mortality also showed association with longer total length of hospital stay, as well as with prolonged postoperative period. Conclusion Hip fractures in the elderly due to osteoporosis indicate a relationship between the sicker profile of the aging elderly population and the prevalence of chronic diseases strongly associated with in-hospital infections, contributing to increased mortality. There were fewer early interventions, and mortality was also associated with prolonged postoperative period. The aim of this study was not to compare independent variables with each other, but suggests the relationship between the presence of comorbidities, which predisposes to the development of infections, directly linked to mortality.

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