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The growth of the elderly population is urging for more suitable biomaterials to allow the performance of better surgical and implant procedures and accelerate the patient’s healing because the elderly are more vulnerable to orthopedic and dental problems. β-phase Ti alloys can improve the mechanical properties of implants by reducing their elastic modulus and, consequently, the effects of stress shielding within bones. Therefore, the objective of this article is to study a novel ternary β-phase alloy of Ti10Mo8Nb produced by an electric arc furnace and rotary forge. The microstructure and mechanical properties of the Ti10Mo8Nb alloy were investigated in order to evaluate its suitability for biomedical applications and compare its characteristics with those present in Ti-alloys commerced or widely researched for prosthetic purposes. A tensile test, Vickers microhardness test, use of microstructure of optical microscopy for examination of microstructure, X-ray diffraction and hemolysis analysis were carried out. Thus, the Ti10Mo8Nb alloy showed suitable properties for biomedical applications, as well as having the potential to reduce the possibility to occur stress shielding after prosthetic implantations, especially for orthopedics and dentistry.

The purpose of this study is the surface modification of Ti10Mo8Nb experimental alloy by using TiO 2 nanostructure growth. Ingots of the Ti10Mo8Nb experimental alloy were produced by fusion from sheets of molybdenum, niobium, and titanium commercially pure in an arc melting furnace under argon atmosphere. The potentiostatic anodic oxidation was performed using an electrolyte formed of glycerol and H 2 O (1: 1 by vol.) with the addition of 2.7% (w/v) NH 4 F under 20 V for 3 h at room temperature. After the surface treatment, the samples were annealing. The surface of the alloy was analyzed by scanning electron microscopy (SEM), X-ray diffraction (XRD), contact angle, surface energy measurements. In vitro studies, such as cell and bacterial adhesion, were performed to evaluate the response of this treatment. The Ti10Mo8Nb alloy exhibited beta phase after the processing. After the surface treatment, a nanoporous layer of TiO was obtained. The anatase phase was found in the annealed samples (450 ºC for 3 hours). In vitro analyzes showed cell growth viability and decreased bacterial proliferation due to the larger specific surface area.

This study aims to characterize a new Ti-25Ta-25Nb-5Sn alloy for biomedical application. Microstructure, phase formation, mechanical and corrosion properties, along with the cell culture study of the Ti-25Ta-25Nb alloy with Sn content 5 mass% are presented in this article. The experimental alloy was processed in an arc melting furnace, cold worked, and heat treated. For characterization, optical microscopy, X-ray diffraction, microhardness, and Young’s modulus measurements were employed. Corrosion behavior was also evaluated using open-circuit potential (OCP) and potentiodynamic polarization. In vitro studies with human ADSCs were performed to investigate cell viability, adhesion, proliferation, and differentiation. Comparison among the mechanical properties observed in other metal alloy systems, including CP Ti, Ti-25Ta-25Nb, and Ti-25Ta-25-Nb-3Sn showed an increase in microhardness and a decrease in the Young’s modulus when compared to CP Ti. The potentiodynamic polarization tests indicated that the corrosion resistance of the Ti-25Ta-25Nb-5Sn alloy was similar to CP Ti and the experiments in vitro demonstrated great interactions between the alloy surface and cells in terms of adhesion, proliferation, and differentiation. Therefore, this alloy presents potential for biomedical applications with properties required for good performance.

The study of new metallic biomaterials for application in bone tissue repair has improved due to the increase in life expectancy and the aging of the world population. Titanium alloys are one of the main groups of biomaterials for these applications, and beta-type titanium alloys are more suitable for long-term bone implants. The objective of this work was to process and characterize a new Ti10Mo8Nb6Zr beta alloy. Alloy processing involves arc melting, heat treatment, and cold forging. The characterization techniques used in this study were X-ray fluorescence spectroscopy, X-ray diffraction, differential scanning calorimetry, optical microscopy, microhardness measurements, and pulse excitation technique. In vitro studies using adipose-derived stem cells (ADSC) were performed to evaluate the cytotoxicity and cell viability after 1, 4, and 7 days. The results showed that the main phase during the processing route was the beta phase. At the end of processing, the alloy showed beta phase, equiaxed grains with an average size of 228.7 µm, and low Young’s modulus (83 GPa). In vitro studies revealed non-cytotoxicity and superior cell viability compared to CP Ti. The addition of zirconium led to a decrease in the beta-transus temperature and Young’s modulus and improved the biocompatibility of the alloy. Therefore, the Ti10Mo8Nb6Zr alloy is a promising candidate for application in the biomedical field.