1st, 2nd, 3rd and 5th year medical students completed a questionnaire with 35 questions relating to diet, general health, exercise, smoking and drinking. Based on reported 'typical weekly intake' one-third of male non-Asian students in years 1-3, and 59% in year 5 were drinking above safe limits. 12-26% of non-Asian female students were drinking above safe limits. In all years most Asian students were drinking within safe limits. Non-Asians smoked more than Asians and males smoked more than females. A group of non-Asian male students with alcohol intake for the previous week > 35 units was compared with a group of safe drinkers (<25 > 0 units/week). Significantly more of the former group drank > 10 units per occasion, had been hurt as a result of someone's drinking, had caused physical harm and drank at lunch. Although 65% were aware their level of drinking was dangerous, only 7.5% wanted advice on safe drinking and only 5% wanted to drink less. The dangerous level drinkers ate less fruit and smoked more cigarettes than those drinking safely, but there were no other significant differences and there was no evidence for impaired academic performance.

Retrieval tasks can be classified along a continuum from conceptually driven (relying on the encoded meaning of the material) to data driven (relying on the perceptual record and surface features of the material). Since most explicit memory tests are conceptually driven and most implicit memory tests are data driven there has been considerable confounding of the memory system being assessed and the processing required by the retrieval task. The purpose of the present experiment was to investigate the effects of lorazepam on explicit memory, using both types of retrieval task. Lorazepam (2.5 mg) or matched placebo was administered to healthy volunteers and changes in subjective mood ratings and in performance in tests of memory were measured. Lorazepam made subjects significantly more drowsy, feeble, clumsy, muzzy, lethargic and mentally slow. Lorazepam significantly impaired recognition memory for slides, impaired the number of words remembered when the retrieval was cued by the first two letters and reduced the number of pictures remembered when retention was cued with picture fragments. Thus episodic memory was impaired whether the task used was conceptually driven (as in slide recognition) or data driven, as in the other two tasks. Analyses of covariance indicated that the memory impairments were independent of increased sedation, as assessed by self-ratings. In contrast to the deficits in episodic memory, there were no lorazepam-induced impairments in tests of semantic memory, whether this was measured in the conceptually driven task of category generation or in the data-driven task of wordstem completion.