ii 4.1.2 The New Conditions 44 4.1.3 The Existence of EVL for General Stationary Stochastic Processes under Weaker Hypotheses 46 4.1.4 Proofs of Theorem 4.1.4 and Corollary 4.1.5 48 4.2 Extreme Values for Dynamically Defined Stochastic Processes 53 4.2.1 Observables and Corresponding Extreme Value Laws 55 4.2.2 Extreme Value Laws for Uniformly Expanding Systems 59 4.2.3 Example 4.2.1 revisited 61 4.2.4 Proof of the Dichotomy for Uniformly Expanding Maps 63 4.3 Point Processes of Rare Events 64 4.3.1 Absence of Clustering 64 4.3.2 Presence of Clustering 65 4.3.3 Dichotomy for Uniformly Expanding Systems for Point Processes 67 4.4 Conditions Д q (u n ), D 3 (u n ), D p (u n ) * and Decay of Correlations 68 4.5 Specific Dynamical Systems where the Dichotomy Applies 71 4.5.1 Rychlik Systems 72 4.5.2 Piecewise Expanding Maps in Higher Dimensions 73 4.6 Extreme Value Laws for Physical Observables 74

Our findings indicate that CNS clinical involvement occurs in ATTR-V30M patients regardless of LT. Longer disease duration after LT can provide the necessary time for transthyretin amyloidosis to progress until it becomes clinically relevant. Highly sensitive imaging methods are needed to identify and monitor brain ATTR. Disease modifying therapies should consider brain TTR as a target.

The changes in eating patterns that have occurred in recent decades are an important cause of obesity. Food intake and energy expenditure are controlled by a complex neural system involving the hypothalamic centers and peripheral satiety system (gastrointestinal and pancreatic hormones). Highly palatable and caloric food disrupts appetite regulation; however, palatable foods induce pleasure and reward. The cafeteria diet is such a palatable diet and has been shown consistently to increase body weight and induce hyperplasia in animal obesity models. Moreover, palatable high-fat foods (such as those of the cafeteria diet) can induce addiction-like deficits in brain reward function and are considered to be an important source of motivation that might drive overeating and contribute to the development of obesity. The mechanism of neural adaptation triggered by palatable foods is similar to those that have been reported for nondrug addictions and long-term drug use. Thus, this review attempts to describe the potential mechanisms that might lead to highly palatable diets, such as the cafeteria diet, triggering addiction, or compulsion through the reward system.