No abstract

Purpose: To investigate the safety and efficacy of vitrectomy (PPV) in managing intraocular complications relating to vasoproliferative tumours of the retina (VPL). Methods: Retrospective study. 17 VPL patients who underwent vitrectomy at Sheffield Teaching Hospital NHS Trust from 2005 to 2020 were included. Patient demographics, clinical characteristics, intraoperative data and surgical outcomes were collected and evaluated. Results: The mean age was 52 years. Indications for PPV included epiretinal membrane (ERM, n=7), vitreous haemorrhage (VH, n=5), retinal detachment (RD, n=3), diagnostic (n=1) and others (n=1). After PPV, 14/17(82.4%) have stabilised vision, and 3/17(17.6%) deteriorated. Subgroup analysis of ERM peel had good outcomes with 6/7(85.7%) noticing improvement or stabilisation of symptoms, mean LogMAR visual acuity improved from 0.719[6/30]±0.267[6/12] to 0.476[6/19]±0.271[6/12]. Patients undergoing surgery for VH also had good outcomes with resolution (and no recurrence) of the haemorrhage in 3/5(60%) and 5/5(100%) with one or more surgeries respectively. Outcomes for RD surgery were LogMAR 2.126[HM]±0.301[6/12] pre-operatively and 1.185[6/95]±0.522[6/19] post-operatively, with one recurrence of retinal detachment. In the ERM group, 3 patients had adjunctive treatment for VPL intraoperatively and 4 patients had none, no difference found between the two groups in terms of outcome or complications. Tumour with thickness of ≥2mm exhibited inferior visual outcomes compared to <2mm (p<0.05). Conclusions: This is one of the largest datasets in looking at outcomes of vitrectomy for complications of VPL. PPV is effective and safe in managing VPL-related intraocular complications with good outcomes and a low rate of complications, especially for patients with ERM and VH.