The relation between cognitive and motor performance was studied in a sample of 378 children aged 5-6. Half of these children had no behavior problems; the others were selected for externalizing (38%) or internalizing problems (12%). Quantitative and qualitative aspects of motor performance were related to several aspects of cognition, after controlling for the influence of attention. No relation between global aspects of cognitive and motor performance was found. Specific positive relations were found between both aspects of motor performance, visual motor integration and working memory, and between quantitative aspects of motor performance and fluency. These findings reveal interesting parallels between normal cognitive and motor development in 5- to 6-year-old children that cannot be ascribed to attention processes.
Using a questionnaire-based study, we assessed the parent-reported prevalence of attention-deficit hyperactivity disorders (ADHDs), autism spectrum disorders, and obsessive-compulsive disorders in a group of 351 males with Duchenne muscular dystrophy. Of the 351 males with Duchenne muscular dystrophy, 11.7% were reported to have a comorbid diagnosis of ADHD, 3.1% had autism spectrum disorder, and 4.8% had obsessive-compulsive disorder. It can be concluded that the incidence of these neuropsychiatric disorders is higher in Duchenne males than in the normal population. This finding, together with recent reports on the higher prevalence of cognitive and learning problems in Duchenne, supports the view that Duchenne muscular dystrophy is not only a muscular disorder but also a disorder affecting the brain. It is important for clinical practice to take in account this heightened association. More research is needed to examine this association and its consequences.
The authors demonstrated a late neuronal activity in the dorsal horn after exposure of the cervical dorsal root ganglion to different radiofrequency modalities, which was not temperature dependent.
We identified eight patients with a distinct magnetic resonance imaging pattern of inhomogeneous cerebral white matter abnormalities and selective involvement of brainstem and spinal tracts. Proton magnetic resonance imaging showed increased lactate in the abnormal white matter. Clinically, the patients had slowly progressive pyramidal, cerebellar, and dorsal column dysfunction. The uniform, highly characteristic magnetic resonance imaging pattern and the similarities in clinical and magnetic resonance spectroscopy findings provide evidence for a new disease entity. Autosomal recessive inheritance is likely.
Objective-This study examined whether neighbourhood level socioeconomic variables have an independent eVect on reported child behaviour problems over and above the eVect of individual level measures of socioeconomic status.
45).Conclusions-Living in a more deprived neighbourhood is associated with higher levels of child problem behaviour, irrespective of individual level socioeconomic status. The additional eVect of the neighbourhood may be attributable to contextual variables such as the level of social cohesion among residents. (J Epidemiol Community Health 2001;55:246-250) As it is known that behaviour problems in children increase the risk for later psychopathology, 1 unravelling the aetiology of early problem behaviour may provide possibilities for prevention of adult mental disorder. Many studies have shown that individual level variables, such as exposure to marital discord or coming from a low income family, are associated with behaviour problems in children. [2][3][4] In addition, behaviour problems occur more frequently in children living in deprived urban areas than in children living in rural communities.5 6 However, whether neighbourhood level socioeconomic variables have an independent eVect on child behaviour problems over and above the eVect of individual level variables has scarcely been studied. Duncan and colleagues have demonstrated that neighbourhood economic conditions and poverty status are powerful correlates of the behaviour of children even after accounting for family structure and maternal education.7 However, most studies on the eVects of neighbourhood on child behaviour have been hampered by the absence of data combining information at the individual, family, and neighbourhood levels in the appropriate statistical model. Thus, most studies on neighbourhood diVerences on child behaviour problems have not taken into account the hierarchical fashion in which such data are organised. Data that are grouped according to neighbourhood are, in statistical terms, part of a multilevel structure, with level one units (individuals) being clustered into level two units (neighbourhoods). Individuals from the same neighbourhood are more similar to each other than individuals from diVerent areas, implying that the variation of reported child behaviour problems is smaller than if it were completely random. A conventional regression technique cannot take into account the variance components of two diVerent levels, thus underestimating the standard errors of regression coeYcients.
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