Loneliness is a common concern among university students, as these individuals experience many of the risk factors associated with loneliness. This experience of loneliness tends to lead to numerous consequences such as negative self-evaluations, anxiety, and depression, which in turn lead to impaired concentration and a decline in academic motivation and performance. The overarching aims of this study were to identify the predictor variable(s) or combination of predictor variables, namely self-esteem, interpersonal communication competence, and media and technology usage, that explain a significant percentage of the variance in loneliness amongst undergraduate university students, as well as to investigate whether differences exist in loneliness with regards to gender, ethnicity, and generational status. The sample consisted of 1,191 South African undergraduate university students between the ages of 18 and 30. This study was non-experimental in nature and a correlational research design was used. The results indicated that the combination of the independent (predictor) variables accounted for 51.9% of the variance in the Loneliness scores of the sample. Interpersonal Communication Competence and Self-esteem served as statistically and practically significant individual predictor variables of the students’ loneliness. Male students and first-generation students tend to be lonelier than female students and non-first-generation students, respectively.